Deghmane Ala-Eddine, Taha Muhamed-Kheir
Institut Pasteur, Invasive Bacterial Infections Unit, 28 Rue du Dr. Roux, CEDEX 15, 75724 Paris, France.
Microorganisms. 2021 Feb 24;9(3):467. doi: 10.3390/microorganisms9030467.
The WHO recently endorsed an ambitious plan, "Defeating Meningitis by 2030", that aims to control/eradicate invasive bacterial infection epidemics by 2030. Vaccination is one of the pillars of this road map, with the goal to reduce the number of cases and deaths due to , , and . The risk of developing invasive bacterial infections (IBI) due to these bacterial species includes genetic and acquired factors that favor repeated and/or severe invasive infections. We searched the PubMed database to identify host risk factors that increase the susceptibility to these bacterial species. Here, we describe a number of inherited and acquired risk factors associated with increased susceptibility to invasive bacterial infections. The burden of these factors is expected to increase due to the anticipated decrease in cases in the general population upon the implementation of vaccination strategies. Therefore, detection and exploration of these patients are important as vaccination may differ among subjects with these risk factors and specific strategies for vaccination are required. The aim of this narrative review is to provide information about these factors as well as their impact on vaccination against the four bacterial species. Awareness of risk factors for IBI may facilitate early recognition and treatment of the disease. Preventive measures including vaccination, when available, in individuals with increased risk for IBI may prevent and reduce the number of cases.
世界卫生组织最近批准了一项宏伟计划，即“到2030年战胜脑膜炎”，该计划旨在到2030年控制/根除侵袭性细菌感染流行。疫苗接种是该路线图的支柱之一，目标是减少由[此处原文缺失细菌种类名称]、[此处原文缺失细菌种类名称]、[此处原文缺失细菌种类名称]和[此处原文缺失细菌种类名称]导致的病例和死亡数量。由于这些细菌种类而发生侵袭性细菌感染（IBI）的风险包括有利于反复和/或严重侵袭性感染的遗传和后天因素。我们在PubMed数据库中进行检索，以确定增加对这些细菌种类易感性的宿主风险因素。在此，我们描述了一些与侵袭性细菌感染易感性增加相关的遗传和后天风险因素。由于实施疫苗接种策略后预计普通人群中的病例数会减少，这些因素的负担预计会增加。因此，对这些患者进行检测和探索很重要，因为这些有风险因素的个体之间疫苗接种情况可能不同，需要特定的疫苗接种策略。本叙述性综述的目的是提供有关这些因素及其对针对这四种细菌种类进行疫苗接种的影响的信息。了解IBI的风险因素可能有助于疾病的早期识别和治疗。对IBI风险增加的个体采取包括疫苗接种在内的预防措施（如可行），可能预防并减少病例数量。
