Diggins Nicole L, Skalsky Rebecca L, Hancock Meaghan H
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Pathogens. 2021 Feb 13;10(2):200. doi: 10.3390/pathogens10020200.
Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion, as well as viral gene expression. Recent evidence points to a critical role for HCMV miRNAs in mediating latency in CD34 hematopoietic progenitor cells through modulation of cellular signaling pathways, including attenuation of TGFβ and EGFR signaling. Moreover, HCMV miRNAs can act in concert with, or in opposition to, viral proteins in regulating host cell functions. Here, we comprehensively review the studies of HCMV miRNAs in the context of latency and highlight the novel processes that are manipulated by the virus using these small non-coding RNAs.
人巨细胞病毒（HCMV）编码22种成熟的微小RNA（miRNA），这些miRNA调节众多细胞过程，包括囊泡运输、细胞周期进程、细胞凋亡和免疫逃逸，以及病毒基因表达。最近的证据表明，HCMV miRNA通过调节细胞信号通路，包括减弱TGFβ和EGFR信号，在介导CD34造血祖细胞潜伏方面发挥关键作用。此外，HCMV miRNA在调节宿主细胞功能方面可与病毒蛋白协同作用或相互拮抗。在此，我们全面综述了HCMV miRNA在潜伏背景下的研究，并强调了病毒利用这些小非编码RNA操纵的新过程。
