Waszczykowska Arleta, Żyro Dominik, Ochocki Justyn, Jurowski Piotr
Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, Zeromskiego 113, 90-549 Łódź, Poland.
Department of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland.
Biomedicines. 2021 Feb 19;9(2):210. doi: 10.3390/biomedicines9020210.
The use of silver preparations in medicine is becoming increasingly popular. The basic aim of this evaluation was to review the literature on the clinical (in vivo) and antibacterial potential of silver preparations in ophthalmic diseases. The second goal was to summarize the results of experimental research on the use of silver preparations in ophthalmology. The third objective was to present a method for stabilizing eye drops containing silver (I) complex. Analysis of the pH stability of the silver (I) complex with metronidazole in the prepared dosage form (eye drops) was carried out. Most silver preparations are clinically used for topical application. Few experimental results indicate the usefulness of intraocular or systemic administration of silver (I) preparations as an alternative or additional therapy in infectious and angiogenic eye diseases. The development of a new formulation increases the stability of the dosage form. New forms of silver (I) products will certainly find application in the treatment of many ophthalmic diseases. One of the most important features of the silver (I) complex is its capacity to break down bacterial resistance. The new eye drops formula can significantly improve comfort of use. Due to their chemical nature, silver (I) compounds are difficult to stabilize, especially in the finished dosage form.
银制剂在医学中的应用越来越广泛。本评估的基本目的是回顾关于银制剂在眼科疾病中的临床（体内）和抗菌潜力的文献。第二个目标是总结银制剂在眼科应用的实验研究结果。第三个目的是提出一种稳定含银（I）络合物眼药水的方法。对制备的剂型（眼药水）中银（I）与甲硝唑络合物的pH稳定性进行了分析。大多数银制剂临床上用于局部应用。少数实验结果表明，眼内或全身应用银（I）制剂作为感染性和血管生成性眼病的替代或辅助治疗是有用的。新剂型的开发提高了剂型的稳定性。新型银（I）产品肯定会在许多眼科疾病的治疗中得到应用。银（I）络合物最重要的特性之一是其破坏细菌耐药性的能力。新的眼药水配方可以显著提高使用舒适度。由于其化学性质，银（I）化合物难以稳定，尤其是在成品剂型中。
