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生存素表达在卵巢癌患者中的预后意义：一项荟萃分析

Prognostic Significance of Survivin Expression in Patients with Ovarian Carcinoma: A Meta-Analysis.

作者信息

Gąsowska-Bajger Beata, Gąsowska-Bodnar Agnieszka, Knapp Paweł, Bodnar Lubomir

机构信息

Institute of Chemistry, Opole University, 45-052 Opole, Poland.

Department of Gynecology and Gynecologic Oncology, Warmia and Masuria Oncology Centre of The Ministry of The Interior and Administration's Hospital, 10-228 Olsztyn, Poland.

出版信息

J Clin Med. 2021 Feb 21;10(4):879. doi: 10.3390/jcm10040879.

DOI:10.3390/jcm10040879
PMID:33669912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7924601/
Abstract

BACKGROUND

Survivin belongs to the protein family of inhibitors of apoptosis (IAP) and is a regulator of the cell cycle and apoptosis. The aim of this study was to assess the clinical and prognostic significance of expression survivin in patients with ovarian cancer.

METHODS

We systematically searched for articles in PubMed, the American Chemical Society (Publications), Medline, the Royal Society of Chemistry, Scopus and the Web of Science. Patient clinical data, overall survival (OS), disease-free survival (DFS), and survivin expression were extracted from individual studies. We performed statistical analysis using the STATA 16 package. Eighteen publications containing data from 2233 patients with ovarian cancer were included in this meta-analysis.

RESULTS

We found an adverse effect of survivin expression on OS (risk ratio (HR): 1.60; 95% confidence interval (CI): 1.33-1.93, = 0.00) but this was not observed on DFS (HR: 1.06; 95% CI: 0.55-2.05, = 0.87). The analysis of clinicopathological parameters showed that survivin expression was associated with the histological grades (G1-2 vs. G3) (odds ratio (OR) = 0.53, 95% CI: 0.34-0.83, = 0.01) and: International Federation Gynecology and Obstetrics (FIGO) stage (I-II vs. III-IV) (OR = 0.22, 95% CI: 0.09-0.55, = 0.00), but it was not significantly correlated with the histological subtype (OR = 1.14, 95% CI: 0.83-1.58, = 0.42).

CONCLUSIONS

Our meta-analysis suggests that survivin expression may be a marker of poor prognosis in ovarian cancer. Survivin expression was associated with parameters of greater aggressiveness of ovarian cancer. Prospective studies are needed to confirm our results indicating that survivin expression can be used as an ovarian cancer biomarker.

摘要

背景

生存素属于凋亡抑制蛋白（IAP）家族，是细胞周期和凋亡的调节因子。本研究旨在评估生存素表达在卵巢癌患者中的临床及预后意义。

方法

我们系统检索了PubMed、美国化学学会（出版物）、Medline、英国皇家化学学会、Scopus和科学网中的文章。从各项研究中提取患者临床数据、总生存期（OS）、无病生存期（DFS）和生存素表达情况。我们使用STATA 16软件包进行统计分析。本荟萃分析纳入了18篇包含2233例卵巢癌患者数据的出版物。

结果

我们发现生存素表达对总生存期有不良影响（风险比（HR）：1.60；95%置信区间（CI）：1.33 - 1.93，P = 0.00），但在无病生存期方面未观察到这种影响（HR：1.06；95% CI：0.55 - 2.05，P = 0.87）。临床病理参数分析表明，生存素表达与组织学分级（G1 - 2与G3）相关（比值比（OR） = 0.53，95% CI：0.34 - 0.83，P = 0.01）以及国际妇产科联盟（FIGO）分期（I - II与III - IV）相关（OR = 0.22，95% CI：0.09 - 0.55，P = 0.00），但与组织学亚型无显著相关性（OR = 1.14，95% CI：0.83 - 1.58，P = 0.42）。

结论

我们的荟萃分析表明，生存素表达可能是卵巢癌预后不良的一个标志物。生存素表达与卵巢癌侵袭性更强的参数相关。需要进行前瞻性研究以证实我们的结果，即生存素表达可作为卵巢癌生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/e87cfec43c15/jcm-10-00879-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/99e2aa8c110a/jcm-10-00879-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/4a117df4f49c/jcm-10-00879-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/39149f389bd3/jcm-10-00879-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/2d9c68211a83/jcm-10-00879-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/4362a4dde8b6/jcm-10-00879-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/e87cfec43c15/jcm-10-00879-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/99e2aa8c110a/jcm-10-00879-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/e2ad1b040ba7/jcm-10-00879-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/71fab3ef4bd5/jcm-10-00879-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/942d183157c4/jcm-10-00879-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/afdb3f83cb8b/jcm-10-00879-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/4a117df4f49c/jcm-10-00879-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/39149f389bd3/jcm-10-00879-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/2d9c68211a83/jcm-10-00879-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/4362a4dde8b6/jcm-10-00879-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c904/7924601/e87cfec43c15/jcm-10-00879-g010.jpg

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