Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
Viruses. 2021 Feb 11;13(2):280. doi: 10.3390/v13020280.
South African women have a high rate of cervical cancer cases, but there are limited data on human papillomavirus (HPV) genotypes in cervical intraepithelial neoplasia (CIN) in the Eastern Cape province, South Africa. A total of 193 cervical specimens with confirmed CIN from women aged 18 years or older, recruited from a referral hospital, were tested for HPV infection. The cervical specimens, smeared onto FTA cards, were screened for 36 HPV types using an HPV direct flow kit. HPV prevalence was 93.5% (43/46) in CIN2 and 96.6% (142/147) in CIN3. HIV-positive women had a significantly higher HPV prevalence than HIV-negative women (98.0% vs. 89.1%, = 0.012). The prevalence of multiple types was significantly higher in HIV-positive than HIV-negative women ( = 0.034). The frequently detected genotypes were HPV35 (23.9%), HPV58 (23.9%), HPV45 (19.6%), and HPV16 (17.3%) in CIN2 cases, while in CIN3, HPV35 (22.5%), HPV16 (21.8%), HPV33 (15.6%), and HPV58 (14.3%) were the most common identified HPV types, independent of HIV status. The prevalence of HPV types targeted by the nonavalent HPV vaccine was 60.9% and 68.7% among women with CIN2 and CIN3, respectively, indicating that vaccination would have an impact both in HIV-negative and HIV-positive South African women, although it will not provide full protection in preventing HPV infection and cervical cancer lesions.
南非女性的宫颈癌发病率很高，但南非东开普省关于宫颈上皮内瘤变（CIN）中人乳头瘤病毒（HPV）基因型的数据有限。共检测了 193 例来自转诊医院的 18 岁及以上女性的宫颈标本，这些女性被确诊为 CIN。使用 HPV 直接流试剂盒，用 FTA 卡涂抹的宫颈标本检测了 36 种 HPV 类型。CIN2 中的 HPV 患病率为 93.5%（43/46），CIN3 中的 HPV 患病率为 96.6%（142/147）。HIV 阳性女性的 HPV 患病率明显高于 HIV 阴性女性（98.0%比 89.1%， = 0.012）。HIV 阳性女性中多种类型的 HPV 患病率明显高于 HIV 阴性女性（ = 0.034）。在 CIN2 病例中，经常检测到的基因型是 HPV35（23.9%）、HPV58（23.9%）、HPV45（19.6%）和 HPV16（17.3%），而在 CIN3 中，HPV35（22.5%）、HPV16（21.8%）、HPV33（15.6%）和 HPV58（14.3%）是最常见的 HPV 类型，与 HIV 状态无关。九价 HPV 疫苗针对的 HPV 类型在 CIN2 和 CIN3 女性中的患病率分别为 60.9%和 68.7%，这表明疫苗接种将对南非 HIV 阴性和 HIV 阳性女性产生影响，尽管它不能提供充分的保护，以预防 HPV 感染和宫颈癌病变。
