AAAS Science & Technology Policy Fellow Hosted by EPA Office of Chemical Safety and Pollution Prevention, Biopesticides and Pollution Prevention Division, Washington, DC 20004, USA.
Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409, USA.
Int J Environ Res Public Health. 2021 Feb 18;18(4):1975. doi: 10.3390/ijerph18041975.
This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.
本文调查了现有的关于胎粪中金属浓度的科学文献。我们分析了大约 32 篇分析胎粪中铝、砷、钡、钙、铬、铜、铁、锂、镁、锰、锌、铅、汞、锰、钼、镍、磷、硒、锡、钒和锌的论文。由于统计数据缺乏细节，无法进行严格的荟萃分析。突出的是，几乎每一项研究都有研究对象体内至少有一种金属的含量似乎很高。胎粪中金属的意义除了表明暴露之外并不明确，尽管一些研究已经将胎粪中的金属与许多不良结果相关联。已经确定了一些悬而未决的问题，如果得到解决，将极大地提高胎粪分析在评估长期妊娠金属暴露方面的效用。其中包括胎粪中检测到的金属的发育和长期意义、母体和胎儿隔室中金属的动力学和相互作用，以及胎粪分析的最佳方法等问题。
