• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Tenascin C 在升主动脉带瓣成形术后心脏逆向重构中的作用。

The Role of Tenascin C in Cardiac Reverse Remodeling Following Banding-Debanding of the Ascending Aorta.

机构信息

Ludwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, 1090 Vienna, Austria.

Bioengineering and Aerospace Engineering Department, Carlos III University of Madrid, 28911 Madrid, Spain.

出版信息

Int J Mol Sci. 2021 Feb 18;22(4):2023. doi: 10.3390/ijms22042023.

DOI:10.3390/ijms22042023
PMID:33670747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7921966/
Abstract

BACKGROUND

Tenascin-C (TN-C) plays a maladaptive role in left ventricular (LV) hypertrophy following pressure overload. However, the role of TN-C in LV regression following mechanical unloading is unknown.

METHODS

LV hypertrophy was induced by transverse aortic constriction for 10 weeks followed by debanding for 2 weeks in wild type (Wt) and TN-C knockout (TN-C KO) mice. Cardiac function was assessed by serial magnetic resonance imaging. The expression of fibrotic markers and drivers (angiotensin-converting enzyme-1, ACE-1) was determined in LV tissue as well as human cardiac fibroblasts (HCFs) after TN-C treatment.

RESULTS

Chronic pressure overload resulted in a significant decline in cardiac function associated with LV dilation as well as upregulation of TN-C, collagen 1 (Col 1), and ACE-1 in Wt as compared to TN-C KO mice. Reverse remodeling in Wt mice partially improved cardiac function and fibrotic marker expression; however, TN-C protein expression remained unchanged. In HCF, TN-C strongly induced the upregulation of ACE 1 and Col 1.

CONCLUSIONS

Pressure overload, when lasting long enough to induce HF, has less potential for reverse remodeling in mice. This may be due to significant upregulation of TN-C expression, which stimulates ACE 1, Col 1, and alpha-smooth muscle actin (α-SMA) upregulation in fibroblasts. Consequently, addressing TN-C in LV hypertrophy might open a new window for future therapeutics.

摘要

背景

Tenascin-C（TN-C）在压力超负荷后左心室（LV）肥厚中发挥适应性作用。然而，TN-C 在机械卸载后 LV 逆重构中的作用尚不清楚。

方法

通过横主动脉缩窄在野生型（Wt）和 TN-C 敲除（TN-C KO）小鼠中诱导 LV 肥厚 10 周，然后再去带 2 周。通过连续磁共振成像评估心功能。在 LV 组织以及 TN-C 处理后的人心成纤维细胞（HCF）中测定纤维化标志物和驱动因子（血管紧张素转换酶-1，ACE-1）的表达。

结果

慢性压力超负荷导致心功能显著下降，与 LV 扩张以及与 TN-C KO 小鼠相比，Wt 小鼠中的 TN-C、胶原 1（Col 1）和 ACE-1 上调有关。Wt 小鼠的逆重构部分改善了心功能和纤维化标志物的表达；然而，TN-C 蛋白表达保持不变。在 HCF 中，TN-C 强烈诱导 ACE 1 和 Col 1 的上调。

结论

当压力超负荷持续足够长的时间以诱导 HF 时，小鼠的逆重构潜力较小。这可能是由于 TN-C 表达的显著上调，刺激了成纤维细胞中 ACE 1、Col 1 和α-平滑肌肌动蛋白（α-SMA）的上调。因此，在 LV 肥厚中解决 TN-C 问题可能为未来的治疗开辟新的窗口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/3e12397b587a/ijms-22-02023-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/7f5bde077d88/ijms-22-02023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/7c7f22d8045c/ijms-22-02023-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/b1fac7b92f7a/ijms-22-02023-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/e3e5c580e036/ijms-22-02023-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/5e64f3f5bfc7/ijms-22-02023-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/3e12397b587a/ijms-22-02023-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/7f5bde077d88/ijms-22-02023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/7c7f22d8045c/ijms-22-02023-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/b1fac7b92f7a/ijms-22-02023-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/e3e5c580e036/ijms-22-02023-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/5e64f3f5bfc7/ijms-22-02023-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d599/7921966/3e12397b587a/ijms-22-02023-g006.jpg

相似文献

1
The Role of Tenascin C in Cardiac Reverse Remodeling Following Banding-Debanding of the Ascending Aorta.Tenascin C 在升主动脉带瓣成形术后心脏逆向重构中的作用。
Int J Mol Sci. 2021 Feb 18;22(4):2023. doi: 10.3390/ijms22042023.
2
Tenascin-C promotes chronic pressure overload-induced cardiac dysfunction, hypertrophy and myocardial fibrosis.Tenascin-C 促进慢性压力超负荷诱导的心脏功能障碍、肥大和心肌纤维化。
J Hypertens. 2018 Apr;36(4):847-856. doi: 10.1097/HJH.0000000000001628.
3
Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload.在慢性压力超负荷的情况下，PPARα基因敲除小鼠的心脏肥大增强。
Cardiovasc Res. 2008 Apr 1;78(1):79-89. doi: 10.1093/cvr/cvn001. Epub 2008 Jan 10.
4
Tenascin-C aggravates ventricular dilatation and angiotensin-converting enzyme activity after myocardial infarction in mice.纤连蛋白 C 加剧心肌梗死后小鼠的心室扩张和血管紧张素转换酶活性。
ESC Heart Fail. 2020 Oct;7(5):2113-2122. doi: 10.1002/ehf2.12794. Epub 2020 Jul 8.
5
Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.结缔组织生长因子抑制可减轻压力超负荷诱导的心力衰竭中的左心室重构和功能障碍。
Hypertension. 2014 Jun;63(6):1235-40. doi: 10.1161/HYPERTENSIONAHA.114.03279. Epub 2014 Mar 31.
6
Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization.Tenascin-C 通过调节巨噬细胞极化加速心肌梗死后的不良心室重构。
Cardiovasc Res. 2019 Mar 1;115(3):614-624. doi: 10.1093/cvr/cvy244.
7
Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice.血管紧张素转换酶抑制剂可预防1型血管紧张素II受体敲除小鼠心肌梗死后的左心室重构。
Heart. 2005 Aug;91(8):1080-5. doi: 10.1136/hrt.2004.035618.
8
Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload.探讨主动脉缩窄诱导的慢性压力超负荷下心衰（逆）重构中双心室改变的特征。
Sci Rep. 2019 Feb 27;9(1):2956. doi: 10.1038/s41598-019-39581-9.
9
Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload.基质金属蛋白酶2的靶向缺失改善慢性压力超负荷小鼠的心肌重塑。
Hypertension. 2006 Apr;47(4):711-7. doi: 10.1161/01.HYP.0000208840.30778.00. Epub 2006 Feb 27.
10
Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice.纤连蛋白-C 可能会加重心肌梗死后小鼠的左心室重构和功能障碍。
Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1072-8. doi: 10.1152/ajpheart.00255.2009. Epub 2010 Jan 15.

引用本文的文献

1
Vascular (dys)function in the failing heart.衰竭心脏中的血管（功能失调）功能
Nat Rev Cardiol. 2025 Jun 22. doi: 10.1038/s41569-025-01163-w.
2
Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy.肌腱蛋白-C在糖尿病性心肌病小鼠模型中引发心血管功能障碍。
Cardiovasc Diabetol. 2025 May 31;24(1):235. doi: 10.1186/s12933-025-02780-y.
3
Molecular Imaging of Fibroblast Activation Protein in Response to Cardiac Injury Using [Ga]Ga-DATA.SA.FAPi.使用[镓]镓-DATA.SA.FAPi对成纤维细胞活化蛋白在心脏损伤反应中的分子成像

本文引用的文献

1
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart.心脏衰竭中心外基质重构的多尺度分析。
Circ Res. 2021 Jan 8;128(1):24-38. doi: 10.1161/CIRCRESAHA.120.317685. Epub 2020 Oct 27.
2
Mechanical circulatory support does not reduce advanced myocardial fibrosis in patients with end-stage heart failure.机械循环支持并未减少终末期心力衰竭患者的晚期心肌纤维化。
Eur J Heart Fail. 2021 Feb;23(2):324-334. doi: 10.1002/ejhf.2021. Epub 2020 Nov 12.
3
Tenascin-C aggravates ventricular dilatation and angiotensin-converting enzyme activity after myocardial infarction in mice.
Pharmaceuticals (Basel). 2025 Apr 29;18(5):658. doi: 10.3390/ph18050658.
4
Alterations in Coronary Resistance Artery Network Geometry in Diabetes and the Role of Tenascin C.糖尿病患者冠状动脉阻力动脉网络几何结构的改变及腱生蛋白C的作用
Rev Cardiovasc Med. 2023 Jan 4;24(1):6. doi: 10.31083/j.rcm2401006. eCollection 2023 Jan.
5
The diagnostic value of tenascin-C in acute aortic syndrome.腱生蛋白-C在急性主动脉综合征中的诊断价值
J Geriatr Cardiol. 2024 Mar 28;21(3):359-368. doi: 10.26599/1671-5411.2024.03.001.
6
Beyond the Rhythm: In Silico Identification of Key Genes and Therapeutic Targets in Atrial Fibrillation.超越节律：心房颤动关键基因和治疗靶点的计算机模拟鉴定
Biomedicines. 2023 Sep 25;11(10):2632. doi: 10.3390/biomedicines11102632.
7
Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency.遗传性人类和鼠类醚脂缺乏症的心脏病理学的重叠和独特特征。
Int J Mol Sci. 2023 Jan 18;24(3):1884. doi: 10.3390/ijms24031884.
8
Concomitant elevated serum levels of tenascin, MMP-9 and YKL-40, suggest ongoing remodeling of the heart up to 3 months after cardiac surgery after normalization of the revascularization markers.在心脏血运重建标志物恢复正常后，在心脏手术后 3 个月内，血清中 tenascin、MMP-9 和 YKL-40 水平持续升高，提示心脏持续重构。
Eur J Med Res. 2022 Oct 21;27(1):208. doi: 10.1186/s40001-022-00831-8.
9
Hypertension and Cardiovascular Diseases: From Etiopathogenesis to Potential Therapeutic Targets.高血压与心血管疾病：从病因发病机制到潜在治疗靶点。
Int J Mol Sci. 2022 Jul 13;23(14):7742. doi: 10.3390/ijms23147742.
10
Single Donor Infusion of S-Nitroso-Human-Serum-Albumin Attenuates Cardiac Isograft Fibrosis and Preserves Myocardial Micro-RNA-126-3p in a Murine Heterotopic Heart Transplant Model.单次供体输注 S-亚硝基人血清白蛋白可减轻心肌移植纤维化并保存心肌微小 RNA-126-3p 在小鼠异位心脏移植模型中。
Transpl Int. 2022 Apr 13;35:10057. doi: 10.3389/ti.2022.10057. eCollection 2022.
纤连蛋白 C 加剧心肌梗死后小鼠的心室扩张和血管紧张素转换酶活性。
ESC Heart Fail. 2020 Oct;7(5):2113-2122. doi: 10.1002/ehf2.12794. Epub 2020 Jul 8.
4
Epigenetic modulation of tenascin C in the heart: implications on myocardial ischemia, hypertrophy and metabolism.心脏中 tenascin C 的表观遗传调控：对心肌缺血、肥大和代谢的影响。
J Hypertens. 2019 Sep;37(9):1861-1870. doi: 10.1097/HJH.0000000000002097.
5
Tenascin C: A Potential Biomarker for Predicting the Severity of Coronary Atherosclerosis.Tenascin C：预测冠状动脉粥样硬化严重程度的潜在生物标志物。
J Atheroscler Thromb. 2019 Jan 1;26(1):31-38. doi: 10.5551/jat.42887. Epub 2018 May 17.
6
One-year outcomes after rapid-deployment aortic valve replacement.主动脉瓣置换术后 1 年的结果。
J Thorac Cardiovasc Surg. 2018 Feb;155(2):575-585. doi: 10.1016/j.jtcvs.2017.09.133. Epub 2017 Oct 31.
7
Tenascin-C promotes chronic pressure overload-induced cardiac dysfunction, hypertrophy and myocardial fibrosis.Tenascin-C 促进慢性压力超负荷诱导的心脏功能障碍、肥大和心肌纤维化。
J Hypertens. 2018 Apr;36(4):847-856. doi: 10.1097/HJH.0000000000001628.
8
Relation Between Renin-Angiotensin System Blockers and Survival Following Isolated Aortic Valve Replacement for Aortic Stenosis.肾素-血管紧张素系统阻滞剂与主动脉瓣狭窄单纯主动脉瓣置换术后生存率的关系。
Am J Cardiol. 2018 Feb 15;121(4):455-460. doi: 10.1016/j.amjcard.2017.11.013. Epub 2017 Nov 23.
9
Reverse remodelling and myocardial recovery in heart failure.心力衰竭中的逆重构和心肌恢复。
Nat Rev Cardiol. 2018 Feb;15(2):83-96. doi: 10.1038/nrcardio.2017.139. Epub 2017 Sep 21.
10
Long-term outcomes of a rapid deployment aortic valve: data up to 5 years.快速部署主动脉瓣的长期结果：长达 5 年的数据。
Eur J Cardiothorac Surg. 2017 Aug 1;52(2):281-287. doi: 10.1093/ejcts/ezx103.