Department of Surgery, Far Eastern Memorial Hospital, Pan-Chiao, New Taipei 220, Taiwan.
Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li, Taoyuan 320, Taiwan.
Molecules. 2021 Feb 18;26(4):1083. doi: 10.3390/molecules26041083.
Zinc finger myeloid, nervy, and deformed epidermal autoregulatory factor 1-type containing 8 (Zinc finger MYND-type containing 8, ZMYND8) is a transcription factor, a histone H3-interacting protein, and a putative chromatin reader/effector that plays an essential role in regulating transcription during normal cellular growth. Mutations and altered expression of ZMYND8 are associated with the development and progression of cancer. Increased expression of ZMYND8 is linked to breast, prostate, colorectal, and cervical cancers. It exerts pro-oncogenic effects in breast and prostate cancers, and it promotes angiogenesis in zebrafish, as well as in breast and prostate cancers. In contrast, downregulation of ZMYND8 is also reported in breast, prostate, and nasopharyngeal cancers. ZMYND8 acts as a tumor suppressor in breast and prostate cancers, and it inhibits tumor growth by promoting differentiation; inhibiting proliferation, cell-cycle progression, invasiveness, and metastasis; and maintaining the epithelial phenotype in various types of cancers. These data together suggest that ZMYND8 is important in tumorigenesis; however, the existing data are contradictory. More studies are necessary to clarify the exact role of ZMYND8 in tumorigenesis. In the future, regulation of expression/activity of ZMYND8 and/or its binding partners may become useful in treating cancer.
锌指 MYND 型含 8 蛋白（Zinc finger MYND-type containing 8，ZMYND8）是一种转录因子，一种与组蛋白 H3 相互作用的蛋白，也是一种潜在的染色质阅读器/效应器，在正常细胞生长过程中调节转录发挥着重要作用。ZMYND8 的突变和表达改变与癌症的发生和发展有关。ZMYND8 的表达增加与乳腺癌、前列腺癌、结直肠癌和宫颈癌有关。它在乳腺癌和前列腺癌中发挥致癌作用，并在斑马鱼、乳腺癌和前列腺癌中促进血管生成。相反，ZMYND8 的下调也在乳腺癌、前列腺癌和鼻咽癌中报道。ZMYND8 在乳腺癌和前列腺癌中作为肿瘤抑制因子，通过促进分化、抑制增殖、细胞周期进程、侵袭和转移以及维持各种类型癌症中的上皮表型来抑制肿瘤生长。这些数据共同表明 ZMYND8 在肿瘤发生中很重要；然而，现有数据存在矛盾。需要更多的研究来阐明 ZMYND8 在肿瘤发生中的确切作用。将来，调节 ZMYND8 的表达/活性及其结合伙伴可能有助于治疗癌症。
