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猪肠道中一种拟共生菌的特性分析。

Characterization of , a Proposed Commensal in the Porcine Gut.

作者信息

Summers Katie Lynn, Foster Frey Juli, Arfken Ann M

机构信息

Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, ARS, USDA, Beltsville, MD 20705, USA.

出版信息

J Fungi (Basel). 2021 Feb 17;7(2):146. doi: 10.3390/jof7020146.

Abstract

is a fungus commonly isolated from the gastrointestinal tract and feces of post-weaning pigs. Studies have implicated its ability to positively alter piglet gut health through potential symbioses with beneficial bacteria, including and , in providing amino acids as an energy source for microbial and piglet growth, and it has been found to be positively correlated with short-chain fatty acids in the piglet gut. However, basic mycological information remains limited, hampering studies. In this study, we characterized the growth parameters, biofilm formation ability, susceptibility to antimicrobials, and genetic relatedness of to other fungal isolates. Optimal fungal growth conditions were determined, no antifungal resistance was found against multiple classes of antifungal drugs (azoles, echinocandins, polyenes, or pyrimidine analogues), and dimorphic growth was observed. produced biofilms that became more complex in the presence of supernatant, suggesting positive interactions with this bacterium in the gut, while supernatant decreased density, suggesting an antagonistic interaction. This study characterizes the growth conditions that are optimal for further studies of , which is an important step in defining the role and interactions of in the porcine gut environment.

摘要

是一种常见于断奶仔猪胃肠道和粪便中分离出的真菌。研究表明,它能够通过与有益细菌(包括[细菌名称1]和[细菌名称2])的潜在共生关系,积极改变仔猪肠道健康,为微生物和仔猪生长提供氨基酸作为能量来源,并且已发现它与仔猪肠道中的短链脂肪酸呈正相关。然而,基本的真菌学信息仍然有限,阻碍了相关研究。在本研究中,我们对[真菌名称]的生长参数、生物膜形成能力、对抗菌药物的敏感性以及与其他真菌分离株的遗传相关性进行了表征。确定了最佳真菌生长条件,未发现对多类抗真菌药物(唑类、棘白菌素类、多烯类或嘧啶类似物)的抗真菌耐药性,并观察到二态生长。[真菌名称]产生的生物膜在[细菌名称]上清液存在下变得更加复杂,表明在肠道中与该细菌存在积极相互作用,而[细菌名称]上清液降低了密度,表明存在拮抗相互作用。本研究表征了[真菌名称]的生长条件,这些条件对于进一步研究[真菌名称]是最佳的,这是确定[真菌名称]在猪肠道环境中的作用和相互作用的重要一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4163/7922399/8cbbfb6e39e6/jof-07-00146-g001.jpg

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