Jilg W, Schmidt M, Deinhardt F
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, University of Munich, Federal Republic of Germany.
J Med Virol. 1988 Apr;24(4):377-84. doi: 10.1002/jmv.1890240404.
Two hundred and twelve individuals who failed to respond or responded poorly to hepatitis B vaccination or whose anti-HBs levels had dropped below 10 IU/L at follow-up were revaccinated. Only 18% of initial nonresponders, but 96% of those who responded initially, developed anti-HBs above 10 IU/L after revaccination. In 85% of vaccinees, anti-HBs titres after a fourth immunization were significantly higher than after completion of the first full immunization course, and despite a steeper decline of antibody levels after revaccination, anti-HBs seemed to persist better than after the initial course of three inoculations. All individuals who responded initially and in whom anti-HBs had become undetectable developed antibodies. Response to booster doses was seen after three to five days, and a fifth inoculation given to 23 individuals induced even better responses.
对212名未对乙型肝炎疫苗产生应答或应答不佳，或在随访中抗-HBs水平降至10 IU/L以下的个体进行了再次接种。再次接种后，最初无应答者中只有18%产生了高于10 IU/L的抗-HBs，而最初有应答者中这一比例为96%。在85%的接种者中，第四次免疫后的抗-HBs滴度显著高于首次全程免疫完成后，尽管再次接种后抗体水平下降得更快，但抗-HBs似乎比最初的三针接种疗程后持续时间更长。所有最初有应答且抗-HBs已检测不到的个体都产生了抗体。加强剂量接种后3至5天出现应答，对23名个体进行的第五次接种诱导了更好的应答。
