Diószeghy P, Mechler F
Department of Neurology and Psychiatry, University of Debrecen Medical School, Hungary.
J Neurol. 1988 Jan;235(3):174-6. doi: 10.1007/BF00314312.
Serum creatine kinase (CK) and myoglobin (Mb) levels were measured in patients with different neuromuscular diseases, carriers of X-linked Duchenne-type muscular dystrophy and normal volunteers. The highest levels were found in Duchenne dystrophy and both values decreased in parallel with age. In patients suffering from limb-girdle dystrophy the increases in CK activity and Mb concentration were also pronounced. However, there were families with normal and others with elevated CK and Mb levels in facioscapulohumeral dystrophy. In neurogenic atrophies both CK and Mb levels generally increased only slightly. Serum Mb and CK levels have similar values as indicators of muscle damage in primary and secondary skeletal muscle disorders. The serum Mb level helps in the detection of carriers but is not more sensitive than CK measurement.
对患有不同神经肌肉疾病的患者、X连锁杜兴型肌营养不良症携带者及正常志愿者测定了血清肌酸激酶（CK）和肌红蛋白（Mb）水平。杜兴肌营养不良症患者的这两项指标水平最高，且二者的值均随年龄增长而平行下降。在肢带型肌营养不良症患者中，CK活性和Mb浓度也显著升高。然而，面肩肱型肌营养不良症患者中，有些家族的CK和Mb水平正常，而有些家族则升高。在神经源性萎缩中，CK和Mb水平通常仅略有升高。在原发性和继发性骨骼肌疾病中，血清Mb和CK水平作为肌肉损伤指标具有相似的值。血清Mb水平有助于检测携带者，但并不比CK测量更敏感。
