Gochin P M, Kirby A, Adler M W
Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania.
J Pharmacol Exp Ther. 1988 May;245(2):569-73.
Pupillary fluctuation induced by s.c. injection of morphine sulfate was studied in the rat using an infrared video pupillometer. The frequency and amplitude of the induced fluctuations throughout 47 min after drug injection was quantified using fourier analysis. Pupil fluctuation frequency was for the most part less than 0.25 Hz. The frequency profile showed a systematic increase in fluctuation amplitude with decreasing frequency. Aside from this systematic increase, no other consistent frequency trend was observed. The maximum drug effect occurred at approximately 15 min postinjection and remained constant for the remaining 30 min of the experiment. When fluctuation amplitude for all frequencies was pooled, a statistically significant, dose-dependent increase in fluctuation was found, with a peak effect between 10 and 40 mg/kg. Using frequency analysis techniques, we have demonstrated that pupil fluctuation induced by s.c. morphine administration in the rat is, like the concomitant mydriasis, a dose-related phenomenon.
使用红外视频瞳孔计在大鼠中研究了皮下注射硫酸吗啡引起的瞳孔波动。使用傅里叶分析对药物注射后47分钟内诱发波动的频率和幅度进行了量化。瞳孔波动频率大部分低于0.25Hz。频率分布图显示波动幅度随着频率降低而系统性增加。除了这种系统性增加外，未观察到其他一致的频率趋势。最大药物效应在注射后约15分钟出现，并在实验的其余30分钟内保持恒定。当汇总所有频率的波动幅度时，发现波动有统计学上显著的剂量依赖性增加，峰值效应在10至40mg/kg之间。使用频率分析技术，我们已经证明，皮下注射吗啡在大鼠中引起的瞳孔波动，与伴随的瞳孔散大一样，是一种剂量相关现象。
