Nestlé Research, Nestlé, 1000 Lausanne, Switzerland.
EpidStrategies, Durham, NC 27101, USA.
Int J Environ Res Public Health. 2021 Feb 12;18(4):1785. doi: 10.3390/ijerph18041785.
Obesity is highly prevalent and associated with several adverse outcomes including health-related quality-of-life (HRQoL), work productivity, and activity impairment. The objective of this study is to examine group differences in HRQoL and labor-related health outcomes among participants in the OPTIWIN program, which compared the effectiveness of two intensive behavioral weight loss interventions. Participants ( = 273) were randomized to OPTIFAST(OP) or food-based (FB) dietary interventions for 52 weeks. HRQoL and labor-related health outcomes were measured at baseline, week 26, and week 52, using two questionnaires. At baseline, there were no differences between groups on the Impact of Weight on Quality-of-Life Questionnaire (IWQOL-Lite). At week 26, the OP group had statistically significant differences towards better HRQoL for Physical Function, Self-Esteem, and the total score compared with the FB group. At week 52, the OP group showed better HRQoL in the total score ( = 0.0012) and in all but one domain. Moreover, the adjusted change-from-baseline normalized total score at week 52 was -5.9 points ( = 0.0001). Finally, the mean IWQOL-Lite normalized score showed that HRQoL improves by 0.4442 units ( < 0.0001) per kg lost, and that greater weight reduction was positively associated with better HRQoL. No statistically significant group differences were found with the Work Productivity and Activity Impairment (General Health) (WPAI-GH) Questionnaire. HRQoL improves with highly intensive, well-structured weight loss interventions. Greater weight loss lead to larger improvements. The lack of negative effect on productivity and activity suggests that these interventions may be compatible with an active work lifestyle.
肥胖症的发病率很高，与多种不良后果相关，包括与健康相关的生活质量（HRQoL）、工作生产力和活动能力受损。本研究的目的是检验 OPTIWIN 计划参与者在 HRQoL 和与劳动相关的健康结果方面的组间差异，该计划比较了两种强化行为体重减轻干预措施的效果。参与者（n=273）被随机分配到 OPTIFAST（OP）或基于食物的（FB）饮食干预组，为期 52 周。使用两份问卷在基线、第 26 周和第 52 周测量 HRQoL 和与劳动相关的健康结果。在基线时，两组在体重对生活质量影响问卷（IWQOL-Lite）上没有差异。在第 26 周，与 FB 组相比，OP 组在身体功能、自尊和总分方面的 HRQoL 有统计学上的显著改善。在第 52 周，OP 组在总分（ = 0.0012）和除一个领域外的所有领域都显示出更好的 HRQoL。此外，第 52 周的基线调整后归一化总分变化为-5.9 分（ = 0.0001）。最后，IWQOL-Lite 归一化平均得分表明，每减轻 1 公斤体重，HRQoL 可改善 0.4442 个单位（ < 0.0001），体重减轻越多与 HRQoL 改善越显著相关。在工作生产力和活动障碍（一般健康）（WPAI-GH）问卷上没有发现统计学上的组间差异。高度强化、结构良好的减肥干预措施可改善 HRQoL。更大的体重减轻会带来更大的改善。对生产力和活动没有负面影响表明，这些干预措施可能与积极的工作生活方式兼容。
