IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Int J Mol Sci. 2021 Feb 12;22(4):1844. doi: 10.3390/ijms22041844.
Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even "paradigmatic", shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor "aryl hydrocarbon receptor" (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.
确定历史轨迹在研究中是一项有用的工作，因为它有助于阐明思维的重要转变，甚至可能是“范式”转变，从而推动科学的发展。在这篇综述中，讨论了转录因子“芳香烃受体”（AHR）作为环境污染毒性的介质的研究进展，以及其与环境和免疫系统健康适应反应之间的联系。从这一引人入胜的发展中，可以清楚地看到靶向 AHR 在许多疾病治疗中的机会。
