Fedele L, Zamberletti D, D'Alberton A, Vercellini P, Candiani G B
First Department of Obstetrics and Gynecology, University of Milan, Italy.
J Reprod Med. 1988 Apr;33(4):353-5.
The reproductive history was analyzed of 13 women with a laparoscopic or laparotomy diagnosis of uterus didelphys and followed for two to six years. Two patients (15.4%) presented with primary infertility; the other 11 had a total of 27 pregnancies, the outcome of which was spontaneous abortion in 20 cases (74%), premature labor in 6 (22.2%) and term birth in 1 (3.7%), with a live birth rate of 18.5%. Metroplasty was performed in five cases, with live birth in three, spontaneous abortion in 1 and no postoperative conceptions in one. Cervical cerclage was performed in only one case and bilateral ovarian resection in one. The live birth rate, considering all pregnancies before and after treatment, was 35%. The compromised fertility of the uterus didelphys is probably attributable to congenital alterations in vascularization that may have a negative influence on developmental phases following implantation, particularly the structuralization of the fetomaternal relations that precede placentation.
对13例经腹腔镜或剖腹手术诊断为双子宫并随访2至6年的女性的生殖史进行了分析。2例患者（15.4%）表现为原发性不孕；其他11例共有27次妊娠，其中20例（74%）的结局为自然流产，6例（22.2%）为早产，1例（3.7%）为足月分娩，活产率为18.5%。5例行子宫成形术，其中3例活产，1例自然流产，1例术后未受孕。仅1例行宫颈环扎术，1例行双侧卵巢切除术。考虑治疗前后的所有妊娠，活产率为35%。双子宫生育力受损可能归因于血管形成的先天性改变，这可能对着床后的发育阶段产生负面影响，特别是胎盘形成前母胎关系的结构化。
