Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against by Commensal .

is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against is important for elucidating the mechanisms by which is able to colonize the gut after antibiotics. Commensal play a key role in colonization resistance. They are able to modify bile acids which alter the life cycle. Commensal also produce other inhibitory metabolites including antimicrobials and short chain fatty acids. They also compete with for vital nutrients such as proline. Understanding the mechanistic effects that these metabolites have on and other gut pathogens is important for the development of new therapeutics against infection (CDI), which are urgently needed.