共生菌产生的抑制性代谢产物和营养物质竞争对抵抗[病原体名称]定殖抗性的贡献 。 需注意，原文中“by Commensal.”部分表述不完整，推测可能是“by Commensal bacteria”之类的，以上译文是基于现有内容尽量完善后的结果。
Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against by Commensal .
作者信息
Reed Amber D, Theriot Casey M
机构信息
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
出版信息
Microorganisms. 2021 Feb 12;9(2):371. doi: 10.3390/microorganisms9020371.
is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against is important for elucidating the mechanisms by which is able to colonize the gut after antibiotics. Commensal play a key role in colonization resistance. They are able to modify bile acids which alter the life cycle. Commensal also produce other inhibitory metabolites including antimicrobials and short chain fatty acids. They also compete with for vital nutrients such as proline. Understanding the mechanistic effects that these metabolites have on and other gut pathogens is important for the development of new therapeutics against infection (CDI), which are urgently needed.
是一种厌氧病原体，可导致严重的发病率和死亡率。了解针对该病原体的定植抗性机制对于阐明其在抗生素治疗后能够在肠道定植的机制很重要。共生菌在定植抗性中起关键作用。它们能够修饰胆汁酸，从而改变该病原体的生命周期。共生菌还会产生其他抑制性代谢产物，包括抗菌剂和短链脂肪酸。它们还会与该病原体竞争脯氨酸等重要营养素。了解这些代谢产物对该病原体和其他肠道病原体的作用机制对于开发针对艰难梭菌感染（CDI）的新疗法很重要，而这是迫切需要的。
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