UCIBIO-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Nova University of Lisbon, Portugal; LAQV-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Nova University of Lisbon, Portugal; CENIMAT/I3N, Physics Department, Faculty of Sciences and Technology, Nova University of Lisbon, Portugal.
UCIBIO-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Nova University of Lisbon, Portugal.
Carbohydr Polym. 2021 May 1;259:117761. doi: 10.1016/j.carbpol.2021.117761. Epub 2021 Feb 9.
This study reports the performance of FucoPol, a fucose-containing bacterial polysaccharide, as a photostable agent with high absorption yield at concentrations as low as 0.02 % (w/v). FucoPol is non-cytotoxic, efficiently protects from UVA and UVB at concentrations of 0.02-2 % (w/v) and 0.2-2 % (w/v), respectively, has over 94 % overall photostability up to 1.5 h of irradiation time. The lowest concentration studied (0.02 %, w/v) shows a sun protection factor (SPF) of 2.61 ± 0.08. The SPF-to-concentration unit ratio showed that FucoPol is about 60-fold more photoprotective than combinations of common organic and inorganic UV filters. In vitro radiation exposure experiments of adhered Vero epithelial and PM1 keratinocytic cells in the presence of 0.25 % (w/v) FucoPol further showed that cell viability was preserved, and delayed radiation-induced cell death was prevented. Overall, FucoPol outperforms common cosmetic biopolymers like xanthan and fucogel. These results are very promising for the development of bio-based sunscreen formulations.
本研究报告了 FucoPol（一种含岩藻糖的细菌多糖）作为光稳定剂的性能，其在低至 0.02%（w/v）的浓度下即可具有高吸收产率。FucoPol 是非细胞毒性的，在 0.02-2%（w/v）和 0.2-2%（w/v）的浓度下，分别有效地保护 UVA 和 UVB，在 1.5 小时的辐照时间内具有超过 94%的整体光稳定性。研究的最低浓度（0.02%，w/v）显示出 2.61±0.08 的防晒因子（SPF）。SPF 与浓度单位的比值表明，FucoPol 的光保护作用比常见的有机和无机紫外线滤光剂的组合强约 60 倍。在存在 0.25%（w/v）FucoPol 的附着 Vero 上皮和 PM1 角质形成细胞的体外辐射暴露实验中，还表明细胞活力得以保持，并且防止了辐射诱导的细胞死亡的延迟。总体而言，FucoPol 优于 xanthan 和 fucogel 等常见的化妆品生物聚合物。这些结果非常有希望用于开发基于生物的防晒霜配方。
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