卵巢癌免疫学的 ABC ：IgA、B 细胞和 CTL。
The ABCs of ovarian cancer immunology: IgA, B cells, and CTLs.
机构信息
Department of Pathology Brigham and Women's Hospital, 77 Avenue Louis Pasteur Boston, MA, USA. Email:
出版信息
Sci Immunol. 2021 Mar 5;6(57). doi: 10.1126/sciimmunol.abh3184.
PMID:33674323
Abstract
Intratumoral B cells in ovarian cancers produce IgA, which binds tumor antigens and inhibit tumor growth through myeloid cell-dependent mechanisms or by neutralization of secreted factors, and by antigen-nonspecific binding to poly-Ig receptor on cancer cells leading to transcytosis, which sensitizes the cells for CTL killing.
摘要
卵巢癌中的肿瘤内 B 细胞产生 IgA，它通过髓样细胞依赖的机制或中和分泌因子来结合肿瘤抗原并抑制肿瘤生长，通过非特异性结合癌细胞上的多 Ig 受体导致转胞吞作用，从而使细胞对 CTL 杀伤敏感。
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