APOL1 变异等位基因与 HIV 感染中机会性感染的风险降低相关。
APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection.
机构信息
Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
Commun Biol. 2021 Mar 5;4(1):284. doi: 10.1038/s42003-021-01812-z.
Apolipoprotein L1 (APOL1), an innate immune factor against African trypanosoma brucei, inhibits HIV-1 in vitro. The impact of APOL1 G1-G2 variants on HIV-1-associated opportunistic infections (OIs) is unknown. Here, we report findings from a metaanalysis of four HIV/AIDS prospective cohorts (ALIVE, LSOCA, MACS, and WIHS) including 2066 African American participants. Using a global test combining all four cohorts, carriage of two APOL1 variant alleles is associated with a 50% reduction in odds of OI (combined OR 0.50, 95% CI 0.33-0.76). Subgroup analysis of OI etiological categories (viral, parasitic, fungal and Mycobacterial) suggests the possibility of specific protection from fungal infections (OR 0.54. 95% CI 0.32-0.93; P = 0.08). We observe an association of APOL1 variant alleles with host protection against OI in HIV-positive individuals. The study suggests a broader role of APOL1 variant alleles in innate immunity in vivo.
载脂蛋白 L1（APOL1）是一种针对非洲锥虫的天然免疫因子，可在体外抑制 HIV-1。APOL1 G1-G2 变体对 HIV-1 相关机会性感染（OIs）的影响尚不清楚。在这里，我们报告了对四项 HIV/AIDS 前瞻性队列（ALIVE、LSOCA、MACS 和 WIHS）的荟萃分析结果，其中包括 2066 名非裔美国参与者。使用结合了所有四个队列的全球检验，携带两个 APOL1 变体等位基因与 OI 发生几率降低 50%相关（合并 OR 0.50，95%CI 0.33-0.76）。对 OI 病因类别（病毒、寄生虫、真菌和分枝杆菌）的亚组分析表明，可能对真菌感染有特定的保护作用（OR 0.54，95%CI 0.32-0.93；P=0.08）。我们观察到 APOL1 变体等位基因与 HIV 阳性个体中 OI 的宿主保护之间存在关联。该研究提示 APOL1 变体等位基因在体内天然免疫中具有更广泛的作用。
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