Departments of Ophthalmology and Visual Sciences.
Internal Medicine, University of Michigan, Ann Arbor, MI.
J Glaucoma. 2021 Aug 1;30(8):744-749. doi: 10.1097/IJG.0000000000001824.
Higher levels of near vision-related quality of life (VRQoL) were associated with higher adherence to glaucoma medications after adjusting for important confounding variables among participants in the Support, Educate, Empower (SEE) personalized glaucoma coaching pilot study.
To investigate the association between VRQoL and glaucoma medication adherence.
Subjects were recruited for the SEE program, a prospective noncontrolled cohort study examining the impact of a personalized coaching program on glaucoma medication adherence. Glaucoma patients seen at the University of Michigan over 40 years old, taking ≥1 glaucoma medication, and self-reported poor adherence on 2 validated scales were recruited. Demographic details and VRQoL using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) were collected. Participants' medication use for each prescribed glaucoma medication was captured electronically using a medication events monitoring system. The association between VRQoL and medication adherence was assessed with Pearson correlation coefficient (r) and linear regression.
Among the 95 eligible participants 49.5% were female, 55.3% were Caucasian, and mean age (±SD) was 63.8±10.5 years. Mean adherence to glaucoma medication was 73.8%±21.0%. Mean NEI VFQ-25 composite score was 81.6±14.5. Better medication adherence was significantly and positively correlated with better functioning in domains of ocular pain (r=0.20, P=0.048), near activities (r=0.29, P=0.004), and role difficulties (r=0.22, P=0.036). Linear regression models adjusting for known correlates of medication adherence (age, sex, race, income), showed a 10-unit increase in self-perceived near activities function was associated with a 2.2% increase in medication adherence (95% confidence interval, 1.0%-5.4%; P=0.0056).
Better self-perceived near activities function was associated with increased glaucoma medication adherence.
在调整了支持、教育、赋权（SEE）个性化青光眼教练试点研究参与者中的重要混杂变量后，较高的近视力相关生活质量（VRQoL）水平与青光眼药物治疗的更高依从性相关。
调查 VRQoL 与青光眼药物治疗依从性之间的关系。
参与者被招募参加 SEE 计划，这是一项前瞻性非对照队列研究，旨在检查个性化教练计划对青光眼药物治疗依从性的影响。在密歇根大学就诊的年龄超过 40 岁、服用≥1 种青光眼药物且在 2 种经过验证的量表上报告药物依从性差的青光眼患者被招募。收集人口统计学细节和使用 25 项国家眼科研究所视觉功能问卷（NEI VFQ-25）的 VRQoL。使用药物事件监测系统电子记录每位患者每种处方青光眼药物的使用情况。使用 Pearson 相关系数（r）和线性回归评估 VRQoL 与药物治疗依从性之间的关系。
在 95 名符合条件的参与者中，49.5%为女性，55.3%为白种人，平均年龄（±SD）为 63.8±10.5 岁。青光眼药物治疗的平均依从率为 73.8%±21.0%。平均 NEI VFQ-25 综合评分 81.6±14.5。更好的药物治疗依从性与眼部疼痛（r=0.20，P=0.048）、近距离活动（r=0.29，P=0.004）和角色困难（r=0.22，P=0.036）等功能领域的改善呈显著正相关。调整药物治疗依从性的已知相关因素（年龄、性别、种族、收入）后，线性回归模型显示，自我感知的近视力功能提高 10 个单位与药物治疗依从性提高 2.2%相关（95%置信区间，1.0%-5.4%；P=0.0056）。
自我感知的近视力功能改善与青光眼药物治疗依从性提高有关。
