Challa Feyissa, Gelibo Terefe, Getahun Tigist, Sileshi Meron, Geto Zeleke, Bekele Abebe, Getachew Theodros, Defar Atkure, Teklie Habtamu, Nagasa Bikila, Girma Fisume, Seifu Daniel, Tebeje Solomon, Teferra Solomon, Wolde Mistire, Carobene Anna, Abate Ebba
National Reference Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
ICAP-Columbia University, Addis Ababa, Ethiopia.
Clin Chim Acta. 2021 Jun;517:99-107. doi: 10.1016/j.cca.2021.02.013. Epub 2021 Mar 4.
C-reactive protein (CRP) is an important inflammatory marker associated with different disease conditions, and its concentration differs among ethnicity. This study aimed to determine the distribution and determinants of serum high-sensitive method CRP (hsCRP) that can measure the typically low concentrations, among the Ethiopian population, for which there is no data.
A cross-sectional community-based study was conducted in April-June 2015. A total of 5162 individuals aged 15-69 were included. Behavioral, physical, and biochemical measurements were taken using the WHO STEPS non-communicable diseases (NCDs) risk factors assessment tool. Serum hsCRP was determined using Cobas Integra 400 Plus (Roche). Factors associated with hsCRP levels were also considered.
median hsCRP was 0.80 mg/L (Interquartile range, 0.19-2.12) (males: 0.91 mg/L, females: 0.74 mg/L). More than 18% of the study participants had hsCRP greater than 3 mg/L according to the American Heart Association and Centers for Diseases Control and Preventions cut off value. Higher BMI, living in Somali and in Dire Dawa region, and not consuming of fruit or vegetables were independent risk factors for high hsCRP levels.
Serum hsCRP levels distribution is comparable to other studies. Until now, no data have been reported in the literature about the Ethiopian population.
C反应蛋白（CRP）是一种与不同疾病状况相关的重要炎症标志物，其浓度在不同种族间存在差异。本研究旨在确定血清高敏CRP（hsCRP）（一种能够检测典型低浓度CRP的方法）在埃塞俄比亚人群中的分布情况及其决定因素，目前尚无该人群的相关数据。
2015年4月至6月开展了一项基于社区的横断面研究。共纳入5162名年龄在15 - 69岁的个体。使用世界卫生组织的“STEPS非传染性疾病（NCDs）风险因素评估工具”进行行为、身体和生化指标测量。采用Cobas Integra 400 Plus（罗氏公司）测定血清hsCRP。同时考虑与hsCRP水平相关的因素。
hsCRP中位数为0.80mg/L（四分位间距，0.19 - 2.12）（男性：0.91mg/L，女性：0.74mg/L）。根据美国心脏协会和疾病控制与预防中心的临界值，超过18%的研究参与者hsCRP大于3mg/L。较高的体重指数、居住在索马里和德雷达瓦地区以及不食用水果或蔬菜是hsCRP水平升高的独立危险因素。
血清hsCRP水平分布与其他研究结果相当。迄今为止，文献中尚未报道过埃塞俄比亚人群的相关数据。
