Yoshida Soichiro, Takahara Taro, Arita Yuki, Sakaino Shinjiro, Katahira Kazuhiro, Fujii Yasuhisa
Department of Urology, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Biomedical Engineering, Tokai University School of Engineering, Kanagawa, Japan.
Int J Urol. 2021 May;28(5):502-513. doi: 10.1111/iju.14497. Epub 2021 Mar 6.
The diffusion-weighted imaging signal is derived from the motion of water molecules. It represents the physiological characteristics of tissue and is an essential imaging sequence for prostate cancer. Whole-body diffusion-weighted imaging facilitates the assessment of pathological conditions throughout the body. The concept of diffusion-weighted whole-body imaging with background body signal suppression and technological advances has led to routine clinical deployment of whole-body diffusion-weighted imaging as a one-step staging tool for prostate cancer. Furthermore, whole-body diffusion-weighted imaging has the potential to reveal the state of osseous lesions, for which conventional imaging techniques are suboptimal for monitoring the response to therapy, and extraosseous lesions, and holds promise as a new imaging-based therapeutic approach. This article reviews the basics of whole-body diffusion-weighted imaging, and focuses on application of whole-body diffusion-weighted imaging in the clinical management of prostate cancer at various stages in the course of the disease.
扩散加权成像信号源自水分子的运动。它代表组织的生理特征，是前列腺癌的重要成像序列。全身扩散加权成像有助于评估全身的病理状况。背景体部信号抑制的扩散加权全身成像概念及技术进步，使得全身扩散加权成像作为前列腺癌的一步分期工具得以常规临床应用。此外，全身扩散加权成像有潜力揭示骨病变的状态，而传统成像技术在监测骨病变对治疗的反应方面效果欠佳，同时它还能发现骨外病变，并有望成为一种基于成像的新治疗方法。本文综述了全身扩散加权成像的基础知识，并重点关注其在前列腺癌疾病进程不同阶段临床管理中的应用。
