Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 Haus B, 24105, Kiel, Germany.
Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 Haus B, 24105, Kiel, Germany.
J Craniomaxillofac Surg. 2021 Aug;49(8):726-731. doi: 10.1016/j.jcms.2021.02.022. Epub 2021 Feb 26.
The aim of this animal study was to investigate the effect of platelet-rich plasma (PRP) injections into the temporomandibular joint (TMJ) to treat antigen-induced arthritis AIA. AIA was induced via the application of bovine serum albumin (BSA) into the TMJ. Clear histological signs and protein analysis results indicating inflammation of the TMJ were observed. Afterwards, two PRP injections were performed over an interval of 2 weeks. Concentration levels of the proinflammatory cytokines IL-1β (PRP: 33.7 ± 5.6 pg/mg, untreated: 50.0 ± 2.9 pg/mg; p = 0.04) and TNF-α (PRP: 20.7 ± 2.5 pg/mg, untreated: 31.4 ± 2.7 pg/mg; p = 0.03) were significantly decreased in the PRP-treated joints. A significant reduction in signs of histological inflammation, such as hyperplasia of the synovial membrane, leucocyte infiltration, cartilage surface alterations, and an increase in cartilage-specific glycosaminoglycan content, was observed. This animal study supports the understanding of the underlying effects of PRP treatment in the TMJ, and may enhance novel PRP therapies in the future.
本动物研究旨在探讨富血小板血浆（PRP）注射到颞下颌关节（TMJ）治疗牛血清白蛋白（BSA）诱导的关节炎（AIA）的效果。通过将 BSA 应用于 TMJ 来诱导 AIA。观察到 TMJ 出现明显的组织学迹象和蛋白分析结果，表明存在炎症。之后，在 2 周的间隔内进行了两次 PRP 注射。PRP 治疗关节中促炎细胞因子 IL-1β（PRP：33.7±5.6 pg/mg，未治疗：50.0±2.9 pg/mg；p=0.04）和 TNF-α（PRP：20.7±2.5 pg/mg，未治疗：31.4±2.7 pg/mg；p=0.03）的浓度水平明显降低。观察到滑膜增生、白细胞浸润、软骨表面改变和软骨特异性糖胺聚糖含量增加等组织学炎症迹象明显减少。这项动物研究支持对 PRP 治疗 TMJ 潜在作用的理解，并可能增强未来新的 PRP 治疗方法。
