Henriksen J H, Lassen N A
Department of Clinical Physiology, Hvidovre Hospital, University of Copenhagen, Denmark.
Liver. 1988 Apr;8(2):88-94.
A model of pressure profile along the sinusoids in the liver is presented. The major prerequisite is a converging sinusoidal flow pattern through a network of tubes with almost equal diameter. In this case the main hemodynamic resistance is located downstream at the outlet. Different geometric configurations (sphere, cylinder, and sections of these) are considered, and it is concluded that the precise shape of the microcirculatory unit is not crucial. The applicability in cirrhosis is considered in relation to a decreased diameter and number of the sinusoids in this condition. Estimated pressure profiles along the sinusoids indicate a steep downstream pressure fall in cirrhosis, implying that the spatial average of sinusoidal pressure is close to that of the inlet, i.e. portal pressure. Another prediction is an increased blood flow rate (flow rate per vessel) in the region near the outlet of the sinusoids.
本文提出了肝脏中沿肝血窦压力分布的模型。主要前提是通过直径几乎相等的管网实现汇聚的肝血窦血流模式。在这种情况下，主要的血流动力学阻力位于下游出口处。考虑了不同的几何构型（球体、圆柱体及其截面），得出微循环单元的精确形状并不关键的结论。结合肝硬化时肝血窦直径和数量减少的情况，考虑了该模型在肝硬化中的适用性。沿肝血窦估计的压力分布表明，肝硬化时下游压力急剧下降，这意味着肝血窦压力的空间平均值接近入口压力，即门静脉压力。另一个预测是肝血窦出口附近区域的血流速度（每根血管的流速）增加。
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