Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan; Institute of Cyclotron and Drug Discovery Research, Southern TOHOKU Research Institute for Neuroscience, Koriyama, Fukushima 963-8052, Japan; Preparing Section for New Faculty of Medical Science, Fukushima Medical University, Fukushima 960-1295, Japan.
Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan; Department of Radiological Sciences, School of Health Science, International University of Health and Welfare, Otawara, Tochigi 324-8501, Japan.
Phys Med. 2021 Feb;82:249-254. doi: 10.1016/j.ejmp.2021.02.017. Epub 2021 Mar 4.
A standardized method for quantification is required for analyzing PET data, but such standards have not been established for tau PET imaging. The Centiloid scale has recently been proposed as a standard method for quantifying amyloid deposition on PET imaging. Therefore, the present study aimed to apply the Centiloid scale to F-THK5351 PET imaging in Alzheimer's disease (AD).
We acquired F-THK5351 PET, C-PiB PET, and MR images from 47 cognitively normal (CN) individuals and 28 patients with AD with mild to moderate dementia. PET images were spatially normalized to Montreal Neurological Institute space. The PET signals were then normalized using the signal in the reference volume of interest (VOI). Target VOI for specific F-THK5351 retention in AD was extracted by voxel-wise comparison of PET images between the 47 CN individuals and 16 AD patients with moderate dementia. Scale anchor points were defined by the CN individuals as 0-anchor points and by that of the average of the typical AD patients as 100-anchor points.
Specific retention of F-THK5351 was predominant in the angular gyrus, inferior temporal cortex, and parieto-occipital regions in patients with AD. Standardized uptake value ratio (SUVR) of 1.227 and 1.797 were defined as 0- and 100-anchor points, respectively. F-THK5351 PET data could be expressed using the Centiloid scale, with the SUVR of the F-THK5351 PET images converted to Centiloid using our VOI, the standard Centiloid reference VOI, and the following equation: Centiloid = 169.0 × SUVR-204.6.
Centiloid methods can be applied to tau PET imaging using F-THK5351.
分析 PET 数据需要标准化的定量方法，但尚未为 tau PET 成像建立此类标准。最近提出了 Centiloid 量表作为 PET 成像中定量淀粉样蛋白沉积的标准方法。因此，本研究旨在将 Centiloid 量表应用于 F-THK5351 PET 对阿尔茨海默病（AD）的成像。
我们从 47 名认知正常（CN）个体和 28 名轻度至中度痴呆的 AD 患者中采集了 F-THK5351 PET、C-PiB PET 和磁共振图像。将 PET 图像空间标准化到蒙特利尔神经学研究所空间。然后使用参考感兴趣区（ROI）中的信号对 PET 信号进行归一化。通过对 47 名 CN 个体和 16 名中度痴呆的 AD 患者的 PET 图像进行体素比较，提取 AD 患者特定的 F-THK5351 保留的目标 ROI。0-锚点由 CN 个体定义，100-锚点由典型 AD 患者的平均值定义。
AD 患者的角回、下颞叶皮质和顶枕叶区域存在 F-THK5351 的特异性保留。标准化摄取值比（SUVR）为 1.227 和 1.797 分别定义为 0-和 100-锚点。使用我们的 ROI、标准 Centiloid 参考 ROI 和以下方程，可以使用 Centiloid 量表表示 F-THK5351 PET 数据：Centiloid = 169.0×SUVR-204.6。
可以使用 F-THK5351 对 tau PET 成像应用 Centiloid 方法。
