匹莫林所致的舞蹈手足徐动症和横纹肌溶解症。

Pemoline-induced choreoathetosis and rhabdomyolysis.

作者信息

Briscoe J G, Curry S C, Gerkin R D, Ruiz R R

机构信息

Department of Medicine, Good Samaritan Medical Center, Phoenix.

出版信息

Med Toxicol Adverse Drug Exp. 1988 Jan-Dec;3(1):72-6. doi: 10.1007/BF03259933.

DOI:10.1007/BF03259933

PMID:3367787

Abstract

Pemoline is an indirectly acting sympathomimetic with actions similar to amphetamine and methylphenidate. While choreoathetosis is a well-recognised complication of acute or chronic amphetamine abuse, only 3 previous case reports have implicated pemoline in such a movement disorder. We report a 49-year-old man who developed severe choreoathetosis with rhabdomyolysis after markedly increasing his intake of pemoline. Abnormal movements responded to diazepam and completely resolved over 48 hours. He made a complete recovery with supportive care. This is only the second case of pemoline-induced choreoathetosis in an adult reported in the English literature, and the first case of rhabdomyolysis and myoglobinuria complicating choreoathetosis.

摘要

匹莫林是一种间接作用的拟交感神经药，其作用类似于苯丙胺和哌甲酯。虽然舞蹈手足徐动症是急性或慢性苯丙胺滥用的一种公认并发症，但此前仅有3例病例报告表明匹莫林会导致这种运动障碍。我们报告了一名49岁男性，在显著增加匹莫林摄入量后出现了严重的舞蹈手足徐动症并伴有横纹肌溶解。异常运动对安定有反应，并在48小时内完全消失。通过支持性治疗，他完全康复。这是英文文献中报道的第二例成人匹莫林诱发的舞蹈手足徐动症病例，也是第一例伴有横纹肌溶解和肌红蛋白尿的舞蹈手足徐动症并发症病例。