Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Artificial Intelligence and Big-Data Convergence Center, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Endocrinol Metab (Seoul). 2021 Feb;36(1):196-200. doi: 10.3803/EnM.2020.856. Epub 2021 Feb 24.
Although obesity is a risk factor for infection, whether it has the same effect on coronavirus disease 2019 (COVID-19) need confirming. We conducted a retrospective propensity score matched case-control study to examine the association between obesity and COVID-19. This study included data from the Nationwide COVID-19 Registry and the Biennial Health Checkup database, until May 30, 2020. We identified 2,231 patients with confirmed COVID-19 and 10-fold-matched negative test controls. Overweight (body mass index [BMI] 23 to 24.9 kg/m2; adjusted odds ratio [aOR], 1.16; 95% confidence interval [CI], 1.1.03 to 1.30) and class 1 obesity (BMI 25 to 29.9 kg/m2; aOR, 1.27; 95% CI, 1.14 to 1.42) had significantly increased COVID-19 risk, while classes 2 and 3 obesity (BMI ≥30 kg/m2) showed similar but non-significant trend. Females and those <50 years had more robust association pattern. Overweight and obesity are possible risk factors of COVID-19.
尽管肥胖是感染的一个危险因素，但它是否对 2019 年冠状病毒病（COVID-19）有同样的影响还需要证实。我们进行了一项回顾性倾向评分匹配病例对照研究，以检查肥胖与 COVID-19 之间的关联。这项研究包括了全国 COVID-19 登记处和两年一次健康检查数据库的数据，截至 2020 年 5 月 30 日。我们确定了 2231 例确诊的 COVID-19 患者和 10 倍匹配的阴性检测对照。超重（身体质量指数[BMI]23 至 24.9kg/m2；调整后的优势比[aOR]，1.16；95%置信区间[CI]，1.103 至 1.30）和 1 级肥胖（BMI 25 至 29.9kg/m2；aOR，1.27；95%CI，1.14 至 1.42）与 COVID-19 风险显著增加相关，而 2 级和 3 级肥胖（BMI≥30kg/m2）则显示出类似但不显著的趋势。女性和年龄<50 岁的人具有更强的关联模式。超重和肥胖可能是 COVID-19 的危险因素。
