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本文引用的文献

1
Nephron-sparing surgery in the treatment of pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions.保留肾单位手术治疗与Xp11.2易位/TFE3基因融合相关的儿童肾细胞癌
J Pediatr Surg. 2017 Sep;52(9):1492-1495. doi: 10.1016/j.jpedsurg.2017.03.052. Epub 2017 Mar 27.
2
Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusions: Clinical Features, Treatments and Prognosis.与Xp11.2易位/TFE3基因融合相关的肾细胞癌：临床特征、治疗与预后
PLoS One. 2016 Nov 28;11(11):e0166897. doi: 10.1371/journal.pone.0166897. eCollection 2016.
3
Renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions: clinical experience and literature review.与Xp11.2易位/TFE3基因融合相关的肾细胞癌：临床经验及文献综述
Future Oncol. 2015;11(24):3243-52. doi: 10.2217/fon.15.177. Epub 2015 Jul 14.
4
Review of renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions with focus on pathobiological aspect.Xp11.2 易位/TFE3 基因融合相关性肾细胞癌的研究进展：聚焦于病理生物学方面
Histol Histopathol. 2012 Feb;27(2):133-40. doi: 10.14670/HH-27.133.
5
Xp11 translocation renal cell carcinoma.Xp11 易位性肾细胞癌。
Pathology. 2010 Jun;42(4):369-73. doi: 10.3109/00313021003767348.
6
Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network.转移性 Xp11 易位/TFE3 基因融合肾细胞癌（RCC）中的靶向药物：来自青少年 RCC 网络的报告。
Ann Oncol. 2010 Sep;21(9):1834-1838. doi: 10.1093/annonc/mdq029. Epub 2010 Feb 12.
7
Adult Xp11 translocation renal cell carcinoma diagnosed by cytogenetics and immunohistochemistry.通过细胞遗传学和免疫组织化学诊断的成人Xp11易位性肾细胞癌
Clin Cancer Res. 2009 Feb 15;15(4):1170-6. doi: 10.1158/1078-0432.CCR-08-1183.
8
Translocation renal cell carcinoma: lack of negative impact due to lymph node spread.易位性肾细胞癌：淋巴结转移无负面影响。
Cancer. 2008 Apr 1;112(7):1607-16. doi: 10.1002/cncr.23331.
9
Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum.成人Xp11易位性肾细胞癌：临床、病理及基因谱的扩展
Am J Surg Pathol. 2007 Aug;31(8):1149-60. doi: 10.1097/PAS.0b013e318031ffff.
10
TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition.TFE3 融合蛋白通过转录上调激活 MET 信号通路，从而将另一类肿瘤定义为 MET 抑制治疗的候选对象。
Cancer Res. 2007 Feb 1;67(3):919-29. doi: 10.1158/0008-5472.CAN-06-2855.

伴有基因融合且完全缓解的转移性成人Xp11.2易位肾细胞癌

Metastatic adult Xp11.2 translocation renal cell carcinoma with gene fusion in complete remission.

作者信息

Manogna Dharmini, Tenneti Divya, Kramer Zachary

机构信息

Department of Internal Medicine, Rochester General Hospital, Rochester, New York.

Vydehi Institute of Medical Science and Research Center, Bangalore, India.

出版信息

Proc (Bayl Univ Med Cent). 2020 Dec 14;34(2):299-301. doi: 10.1080/08998280.2020.1847946.

DOI:10.1080/08998280.2020.1847946
PMID:33678970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7901435/
Abstract

Xp11 translocation renal cell carcinoma (RCC) accounts for most pediatric cases of RCC but is uncommon in adults. It has an aggressive course in adults with poor response to chemoradiation. We describe a 64-year-old man with Xp11 translocation RCC who achieved complete remission following surgery and chemoimmunotherapy.

摘要

Xp11易位性肾细胞癌（RCC）占小儿RCC的大多数病例，但在成人中并不常见。它在成人中病程进展迅速，对放化疗反应不佳。我们描述了一名64岁患有Xp11易位性RCC的男性患者，其在手术及化疗免疫治疗后实现了完全缓解。