Gröbe H, Seibold H, Ullrich K, Müller-Limmroth S, Ziegler R
Städtische Kinderklinik, Nürnberg.
Monatsschr Kinderheilkd. 1988 Feb;136(2):81-4.
Intensified insulin delivery has attained significant importance in the treatment of insulin-dependent diabetes to avoid microangiopathy involving the retina and kidney. 15 patients have been treated for periods from 2 month to 3 years, 2 years with continuous subcutaneous insulin infusion. All patients have better metabolic control than that achieved with conventional therapy. HbA1c decreased from 7.8% +/- 1.6 (SD) to 6.2% +/- 1.3 (normal value: 3.8-6.5%). Negative features of insulin-pump therapy include hyperglycemias after discontinuation of insulin infusion and cutaneous infection at the catheter site. No severe episodes of hypoglycemia were observed. Acceptability of pump treatment is good in our patients because of improved physical condition and the ability to pursue their usual activities.
强化胰岛素给药在胰岛素依赖型糖尿病的治疗中已变得极为重要，以避免涉及视网膜和肾脏的微血管病变。15名患者接受了2个月至3年的治疗，其中2年采用持续皮下胰岛素输注。所有患者的代谢控制情况均优于传统疗法。糖化血红蛋白（HbA1c）从7.8%±1.6（标准差）降至6.2%±1.3（正常值：3.8 - 6.5%）。胰岛素泵治疗的负面特征包括停止胰岛素输注后的高血糖症以及导管部位的皮肤感染。未观察到严重低血糖发作。由于身体状况改善以及能够进行日常活动，我们的患者对泵治疗的接受度良好。
