Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance, Derio, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.
Front Immunol. 2021 Feb 18;12:640869. doi: 10.3389/fimmu.2021.640869. eCollection 2021.
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common form of chronic liver disease. The histological spectrum of NAFLD ranges from simple steatosis to chronic inflammation and liver fibrosis during Non-Alcoholic Steatohepatitis (NASH). The current view is that innate immune mechanisms represent a key element in supporting hepatic inflammation in NASH. Natural Killer (NK) cells are lymphoid cells and a component of the innate immune system known to be involved in NASH progression. Increasing evidence has shed light on the differential function of circulating and tissue-resident NK cells, as well as on the relevance of metabolism and the microenvironment in regulating their activity. Here, we revisit the complex role of NK cells as regulators of NASH progression as well as potential therapeutic approaches based on their modulation.
非酒精性脂肪性肝病 (NAFLD) 是最常见的慢性肝病。NAFLD 的组织学谱从单纯性脂肪变性到非酒精性脂肪性肝炎 (NASH) 时的慢性炎症和肝纤维化不等。目前的观点认为，先天免疫机制是支持 NASH 肝炎症的关键因素。自然杀伤 (NK) 细胞是淋巴细胞，是先天免疫系统的一个组成部分，已知其参与 NASH 的进展。越来越多的证据表明，循环和组织驻留 NK 细胞的功能具有差异性，以及代谢和微环境在调节其活性方面的相关性。在这里，我们重新审视了 NK 细胞作为 NASH 进展调节剂的复杂作用，以及基于其调节的潜在治疗方法。
