Liu Yong-Hui, Zhao Ye, Wang Xiang-Yang, Cui Hong-Xun
Yong-hui Liu, Department of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.
Ye Zhao, Department of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.
Pak J Med Sci. 2021 Mar-Apr;37(2):520-524. doi: 10.12669/pjms.37.2.2383.
To explore the effect of dexmedetomidine hydrochloride on perioperative inflammation and postoperative lung infection in patients with spinal tuberculosis.
A double-blind control observation was conducted in spinal tuberculosis patients with the use of general anesthesia during the operation. A total of 171 spinal tuberculosis patients who received endotracheal intubation for general anesthesia in Henan University of Chinese Medicine from January 2017 to April 2019 were included. The concentration changes in serum TNF-α and IL-6 were recorded at one hour, six hour and one day after the operation. The incidence of postoperative pulmonary complications of patients were also evaluated.
The results showed that in the experimental group compared with the control group, serum TNF-α and IL-6 concentrations one hour, six hour and one day after the operation were significantly lower (P<0.05). The rate of postoperative pulmonary complications was lower in the experimental group than that in the control group (P<0.05).
Dexmedetomidine hydrochloride has obvious anti-inflammatory effects and can reduce the incidence of pulmonary complications after surgery.
探讨盐酸右美托咪定对脊柱结核患者围手术期炎症及术后肺部感染的影响。
对脊柱结核手术患者采用全身麻醉进行双盲对照观察。纳入2017年1月至2019年4月在河南中医药大学接受全身麻醉气管插管的171例脊柱结核患者。记录术后1小时、6小时和1天血清TNF-α和IL-6的浓度变化。同时评估患者术后肺部并发症的发生率。
结果显示，与对照组相比，实验组术后1小时、6小时和1天血清TNF-α和IL-6浓度显著降低（P<0.05）。实验组术后肺部并发症发生率低于对照组（P<0.05）。
盐酸右美托咪定具有明显的抗炎作用，可降低术后肺部并发症的发生率。
