印度孕妇甲状腺功能减退症的患病率：观察性研究的荟萃分析
Prevalence of Hypothyroidism in Pregnant Women in India: A Meta-Analysis of Observational Studies.
作者信息
Yadav Vikas, Dabar Deepti, Goel Akhil D, Bairwa Mohan, Sood Akanksha, Prasad Pankaj, Agarwal Sanjay S, Nandeshwar Sunil
机构信息
Atal Bihari Vajpayee Government Medical College, Vidisha, India.
All India Institute of Medical Sciences, Bhopal, India.
出版信息
J Thyroid Res. 2021 Feb 19;2021:5515831. doi: 10.1155/2021/5515831. eCollection 2021.
INTRODUCTION
This meta-analysis was conducted to estimate the prevalence of hypothyroidism among pregnant women in India.
METHODS
We searched PubMed, Web of Science, Scopus, Google Scholar, and Shodhganga (Indian thesis repository) for observational studies, providing prevalence of hypothyroidism among pregnant women in India. Systematic study selection and data extraction procedures were followed. Quality assessment of each study was done using JBI critical appraisal checklist. The random effects model was used for pooling the effect sizes. Publication bias was assessed using the funnel plot and rank correlation test. statistics was used to measure heterogeneity across the studies. Heterogeneity in the pooled estimates was further explored with subgroup analyses and meta-regression analysis.
RESULTS
Sixty-one studies were found eligible and included in this review. The pooled estimate of the prevalence of hypothyroidism in pregnant women was 11.07% (95% CI: 8.79-13.84, = 99%). Pooled prevalence estimates of subclinical and overt hypothyroidism are 9.51% (95% CI: 7.48-12.04, = 98%) and 2.74% (95% CI: 2.08-3.58, = 94%).
CONCLUSION
We documented 11.07% pooled prevalence of hypothyroidism in pregnant women in India.
引言
本荟萃分析旨在估计印度孕妇甲状腺功能减退症的患病率。
方法
我们在PubMed、科学网、Scopus、谷歌学术和Shodhganga（印度论文库）中检索了关于印度孕妇甲状腺功能减退症患病率的观察性研究。遵循系统的研究选择和数据提取程序。使用JBI批判性评价清单对每项研究进行质量评估。采用随机效应模型合并效应量。使用漏斗图和秩相关检验评估发表偏倚。用统计学方法衡量各研究间的异质性。通过亚组分析和Meta回归分析进一步探讨合并估计值中的异质性。
结果
共纳入61项符合条件的研究。孕妇甲状腺功能减退症患病率的合并估计值为11.07%（95%置信区间：8.79 - 13.84，I² = 99%）。亚临床甲状腺功能减退症和显性甲状腺功能减退症的合并患病率估计值分别为9.51%（95%置信区间：7.48 - 12.04，I² = 98%）和2.74%（95%置信区间：2.08 - 3.58，I² = 94%）。
结论
我们记录了印度孕妇甲状腺功能减退症的合并患病率为11.07%。
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