Zhang Qian, Shaikh Ali Raza, Yoon Thomas, Shah Shreeja, Mahoney James W
Internal Medicine, Abington Hospital- Jefferson Health, Abington, USA.
Cureus. 2021 Jan 31;13(1):e13042. doi: 10.7759/cureus.13042.
Toxic epidermal necrolysis (TEN) is a dermatological emergency that is often associated with high mortality. It is differentiated from Stevens-Johnson syndrome (SJS) based on the percentage of the total body surface area affected. There has been an established correlation with certain medications that could trigger the development of such a devastating disease. Despite numerous research studies conducted on aspects of this disease entity, TEN remains foreign to many general Internists situated in a community setting due to the extremely low disease prevalence that leads to a lack of overall experience and medical resources in dealing with this medical condition. Thus, we outlined several important management aspects of TEN/SJS that an Internist should be aware of in order to assist in prompt clinical decision making and prognosis forecasting as well as deliver effective family communication.
中毒性表皮坏死松解症（TEN）是一种常伴有高死亡率的皮肤科急症。它根据受影响的体表面积百分比与史蒂文斯-约翰逊综合征（SJS）相区分。它与某些可引发这种毁灭性疾病的药物之间存在已确定的关联。尽管针对该疾病实体的各个方面进行了大量研究，但由于疾病患病率极低，导致社区环境中的许多普通内科医生缺乏处理这种病症的总体经验和医疗资源，因此对TEN仍然陌生。因此，我们概述了内科医生应了解的TEN/SJS的几个重要管理方面，以协助迅速进行临床决策和预后预测，并进行有效的医患沟通。
