Pruitt J N, Feringa E R, McBride R L
Medical College of Georgia, Augusta.
Neurology. 1988 Jun;38(6):946-50. doi: 10.1212/wnl.38.6.946.
Ten weeks after complete spinal cord transection at T-9, there was a decrease in the volume of the rat corticospinal tract but no loss in the number of axons contained in the cervical (C-2) or high thoracic (T-1) corticospinal tract. The mean area of the myelinated axon profile decreased in spinal cord-transected rats, with fewer axons found in the largest size groups and more in the smaller size groups. The survival of corticospinal axons in the cervical and thoracic cord 10 weeks after cord transection at T-9 indicates that the corticospinal neurons survive at least 10 weeks after cord transection. The fate of axotomized neurons after longer survival times remains to be determined.
在T-9水平完全横断脊髓10周后，大鼠皮质脊髓束的体积减小，但颈段（C-2）或胸段高位（T-1）皮质脊髓束中的轴突数量没有减少。脊髓横断大鼠的有髓轴突轮廓平均面积减小，在最大尺寸组中发现的轴突较少，而在较小尺寸组中较多。在T-9水平横断脊髓10周后，颈段和胸段脊髓中皮质脊髓轴突的存活表明皮质脊髓神经元在脊髓横断后至少存活10周。轴突切断的神经元在更长存活时间后的命运仍有待确定。
