Banjara Roshan, Kumar Venkatesan Sampath, Khan Shah Alam, Majeed Abdul, Poudel Rishi Ram, Kanwat Himanshu, Thapa Sushma
Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Nepal Cancer Hospital and Research Center, Lalitpur, Nepal.
J Clin Orthop Trauma. 2020 Apr 18;14:162-166. doi: 10.1016/j.jcot.2020.04.014. eCollection 2021 Mar.
It has been indicated in several instances that tall stature is also an important risk factor in the development of osteosarcoma. This relationship between height and osteosarcoma is substantiated even more by the increasing evidences being put forth in the recent literature on dependence of certain tumors on the growth factors and their receptors, acting through autocrine or paracrine mechanisms. There has been no study on the Indian population that attempts to define such a relationship.
The primary objective of this study was to define relationship between height of patients and osteosarcoma at the time of diagnosis in the Indian population.
MATERIALS/METHODS: Retrospective data was collected from the old hospital records. Height of patients at the time of diagnosis was compared with expected height of patients of the same age with reference to the standardized growth charts provided by the Indian Academy of Paediatrics.
Out of 98 patients, there were 65 male and 33 female patients with M: F ratio being 1.97:1. The mean age at diagnosis was 17 (SD = 8) years with range of 5-55 years (median = 17 years). Height of the patients at the time of diagnosis was 155.18 (SD = 15.47) cm with range of 115 cm-184 cm (median = 159 cm). Overall, patients with Osteosarcoma were found to be shorter than the expected height deduced from the national growth charts. When patients were divided into two groups of those who were of growing age and those who had completed growth, results were similar.
The observation that majority of patients with osteosarcoma in our study were stunted, is an important finding. It could be deduced from this observation that these patients are unable to mount the usual biological response to the overstimulated growth as part of tumorigenesis in osteosarcoma. This could point to a different scenario in the Indian population and more studies need to be carried out with larger number of patients to further elaborate on this observation.
在多个实例中已表明，身材高大也是骨肉瘤发生发展的一个重要风险因素。近期文献中越来越多的证据表明某些肿瘤依赖生长因子及其受体，通过自分泌或旁分泌机制发挥作用，这进一步证实了身高与骨肉瘤之间的这种关系。尚未有针对印度人群的研究试图界定这种关系。
本研究的主要目的是界定印度人群中患者身高与诊断时骨肉瘤之间的关系。
材料/方法：从旧的医院记录中收集回顾性数据。根据印度儿科学会提供的标准化生长图表，将诊断时患者的身高与同年龄患者的预期身高进行比较。
98例患者中，男性65例，女性33例，男女比例为1.97:1。诊断时的平均年龄为17（标准差 = 8）岁，范围为5 - 55岁（中位数 = 17岁）。诊断时患者的身高为155.18（标准差 = 15.47）厘米，范围为115厘米至184厘米（中位数 = 159厘米）。总体而言，发现骨肉瘤患者的身高低于根据国家生长图表推算出的预期身高。当将患者分为生长年龄组和生长已完成组时，结果相似。
我们研究中大多数骨肉瘤患者发育迟缓这一观察结果是一项重要发现。由此可以推断，这些患者无法对骨肉瘤发生过程中过度刺激的生长产生通常的生物学反应。这可能表明印度人群存在不同情况，需要对更多患者进行进一步研究以详细阐述这一观察结果。
