Schlagal Caitlin R, Wu Ping
Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX, USA.
Brain Plast. 2020 Dec 29;6(1):41-46. doi: 10.3233/BPL-190091.
Many advancements have been made over the years looking at the individual and combined effects of drugs of abuse on the brain, with one key area of research focusing on the effects on neurogenesis. An integral part of fetal brain development and, later, maintenance in the adult brain, neurogenesis occurs in three main regions: subventricularzone of the lateral ventricles (SVZ), subgranularzone of the dentate gyrus (SGZ), and the tanycyte layer in the hypothalamus (TL). We will review current literature on combined drugs of abuse and their effect on adult neurogenesis. More specifically, this review will focus on the effect of combining cocaine and alcohol. Additionally, the tanycyte layer will be explored in more depth and probed to look at the neurogenic properties of tanycytes and their role in neurogenesis.
多年来，在研究滥用药物对大脑的个体及联合作用方面已取得了许多进展，其中一个关键研究领域聚焦于对神经发生的影响。神经发生是胎儿大脑发育以及之后成人大脑维持的一个重要组成部分，主要发生在三个区域：侧脑室室管膜下区（SVZ）、齿状回颗粒下区（SGZ）以及下丘脑的伸长细胞层（TL）。我们将综述关于滥用药物联合使用及其对成体神经发生影响的当前文献。更具体地说，本综述将聚焦于可卡因和酒精联合使用的影响。此外，将更深入地探讨伸长细胞层，并探究伸长细胞的神经发生特性及其在神经发生中的作用。
