Zhang Bin, Wang Xilei, Cheng Ping
State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2021 Feb 19;10:561372. doi: 10.3389/fonc.2020.561372. eCollection 2020.
Oncolytic viruses (OVs) are potential antitumor agents with unique therapeutic mechanisms. They possess the ability of direct oncolysis and the induction of antitumor immunity. OV can be genetically engineered to potentiate antitumor efficacy by remodeling the tumor immune microenvironment. The present mini review mainly describes the effect of OVs on remodeling of the tumor immune microenvironment and explores the mechanism of regulation of the host immune system and the promotion of the immune cells to destroy carcinoma cells by OVs. Furthermore, this article focuses on the utilization of OVs as vectors for the delivery of immunomodulatory cytokines or antibodies.
溶瘤病毒（OVs）是具有独特治疗机制的潜在抗肿瘤药物。它们具有直接溶瘤和诱导抗肿瘤免疫的能力。通过重塑肿瘤免疫微环境，溶瘤病毒可经基因工程改造以增强抗肿瘤疗效。本综述主要描述了溶瘤病毒对肿瘤免疫微环境重塑的作用，并探讨了宿主免疫系统的调节机制以及溶瘤病毒促进免疫细胞破坏癌细胞的机制。此外，本文重点关注了溶瘤病毒作为免疫调节细胞因子或抗体递送载体的应用。
