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人类复发性疟疾和非人类灵长类动物感染的寄生虫-宿主相互作用和病理生理学研究。

Parasite-Host Interaction and Pathophysiology Studies of the Human Relapsing Malarias and Infections in Non-Human Primates.

机构信息

Department of Parasitology, Biomedical Primate Research Center, Rijswijk, Netherlands.

出版信息

Front Cell Infect Microbiol. 2021 Feb 17;10:614122. doi: 10.3389/fcimb.2020.614122. eCollection 2020.

Abstract

Malaria remains a serious health concern across the globe. Historically neglected, non- human malarias were put back on the agenda by a paradigm shift in the fight against malaria from malaria control to malaria eradication. Here, we review the modeling of the relapsing parasites () and () in non-human primates with a specific focus on the contribution of these models to our current understanding of the factors that govern parasite-host interactions in and parasite biology and pathophysiology.

摘要

疟疾仍然是全球范围内一个严重的健康问题。历史上被忽视的非人类疟原虫,随着疟疾防治模式向疟疾消除的转变,再次成为人们关注的焦点。在这里,我们回顾了在非人类灵长类动物中复发寄生虫()和()的建模,特别关注这些模型对我们当前理解控制和寄生虫生物学和病理生理学中寄生虫-宿主相互作用的因素的贡献。

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