The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China.
Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China.
Biomed Res Int. 2020 Nov 20;2020:4807254. doi: 10.1155/2020/4807254. eCollection 2020.
Hyperoxia-induced acute lung injury (HALI) is a severe side effect of refractory hypoxemia treatment, for which no effective therapeutic strategy is available. Here, we found that the lung miR-21-5p level was significantly decreased in the rats subjected to hyperoxia. Further, we presented evidence that miR-21-5p was a crucial regulator of mitophagy and mitochondrial dysfunction. Moreover, it proved that miR-21-5p regulated hyperoxia-induced mitophagy and mitochondrial dysfunction by directly binding to the target gene PGAM5. In conclusion, for the first time, we found that miR-21-5p could directly suppress mitophagy and mitochondrial damage during HALI formation.
高氧诱导的急性肺损伤 (HALI) 是难治性低氧血症治疗的严重副作用，目前尚无有效的治疗策略。在这里，我们发现高氧处理的大鼠肺中 miR-21-5p 水平显著降低。进一步的，我们提供了证据表明 miR-21-5p 是细胞自噬和线粒体功能障碍的关键调节因子。此外，还证明 miR-21-5p 通过直接与靶基因 PGAM5 结合来调节高氧诱导的细胞自噬和线粒体功能障碍。总之，这是首次发现 miR-21-5p 可以直接抑制 HALI 形成过程中的细胞自噬和线粒体损伤。
