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FDA safety warning on the cardiac effects of lamotrigine: An advisory from the Ad Hoc ILAE/AES Task Force.美国食品药品监督管理局关于拉莫三嗪心脏效应的安全警告：国际抗癫痫联盟/美国癫痫学会特设工作组的一份咨询意见
Epilepsia Open. 2021 Feb 25;6(1):45-48. doi: 10.1002/epi4.12475. eCollection 2021 Mar.
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Investigation of cardiac arrhythmia events in patients treated with lamotrigine: FDA adverse event reporing system analysis.拉莫三嗪治疗患者的心律失常事件调查：FDA 不良事件报告系统分析。
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FDA Safety Warning on the Cardiac Effects of Lamotrigine: An Advisory From the Ad Hoc ILAE/AES Task Force.美国食品药品监督管理局关于拉莫三嗪心脏效应的安全警告：来自国际抗癫痫联盟/美国癫痫学会特设工作组的一份咨询意见
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Lamotrigine may Increase Risk of Arrythmias.拉莫三嗪可能增加心律失常风险。
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PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics.药物基因组学知识库总结：拉莫三嗪途径、药代动力学和药效学。
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A novel approach for pharmacological substantiation of safety signals using plasma concentrations of medication and administrative/healthcare databases: A case study using Danish registries for an FDA warning on lamotrigine.一种使用药物血浆浓度和行政/医疗保健数据库对安全信号进行药理学确证的新方法：以 FDA 对拉莫三嗪警告为例的丹麦登记研究
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Complex hallucinations induced by lamotrigine.拉莫三嗪诱发的复杂幻觉
Rev Neurol (Paris). 2019 Jun;175(6):410-411. doi: 10.1016/j.neurol.2018.11.004. Epub 2019 May 16.

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Epilepsy Care in the Real World of Multiple Medical Considerations.综合多种医学考量的现实世界中的癫痫护理
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Antiseizure medications and their differing effects on cardiovascular risk.抗癫痫药物及其对心血管风险的不同影响。
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A Case of BRASH Syndrome Required Two Hospitalizations in a Short Period.一例BRASH综合征患者在短期内需两次住院治疗。
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Incidence and Types of Cardiac Arrhythmias in the Peri-Ictal Period in Patients Having a Generalized Convulsive Seizure.全面性强直-阵挛发作患者发作间期期心律失常的发生率和类型。
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Antiseizure medication and SUDEP - a need for unifying methodology in research.抗癫痫药物与癫痫猝死——研究中统一方法的必要性。
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Initiation of Antiseizure Medications by US Board-Certified Neurologists After a First Unprovoked Seizure Based on EEG Findings.美国执业认证神经科医生根据脑电图结果在首次无诱因癫痫发作后启动抗癫痫药物治疗的情况。
Neurol Clin Pract. 2024 Feb;14(1):e200249. doi: 10.1212/CPJ.0000000000200249. Epub 2024 Jan 4.
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Challenges and directions in epilepsy diagnostics and therapeutics: Proceedings of the 17th Epilepsy Therapies and Diagnostics Development conference.癫痫诊断与治疗中的挑战与方向：第17届癫痫治疗与诊断发展会议论文集
Epilepsia. 2024 Apr;65(4):846-860. doi: 10.1111/epi.17875. Epub 2024 Jan 5.
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Clinical, imaging, and biomarker evidence of amyloid- and tau-related neurodegeneration in late-onset epilepsy of unknown etiology.病因不明的晚发性癫痫中淀粉样蛋白和tau相关神经变性的临床、影像学和生物标志物证据。
Front Neurol. 2023 Sep 27;14:1241638. doi: 10.3389/fneur.2023.1241638. eCollection 2023.

本文引用的文献

1
Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.实践指南摘要：癫痫性猝死的发病率和危险因素：美国神经病学学会和美国癫痫协会指南制定、传播与实施小组委员会报告
Epilepsy Curr. 2017 May-Jun;17(3):180-187. doi: 10.5698/1535-7511.17.3.180.
2
Signal-averaged and standard electrocardiography in patients with newly diagnosed epilepsy.新诊断癫痫患者的信号平均和标准心电图。
Epilepsy Behav. 2012 Dec;25(4):543-5. doi: 10.1016/j.yebeh.2012.09.023. Epub 2012 Nov 13.
3
Effect of lamotrigine on the PR interval in healthy subjects.拉莫三嗪对健康受试者PR间期的影响。
Br J Clin Pharmacol. 2011 Jun;71(6):961-2. doi: 10.1111/j.1365-2125.2010.03855.x.
4
On the relationship between block of the cardiac Na⁺ channel and drug-induced prolongation of the QRS complex.在心脏钠离子通道阻断与药物引起 QRS 波群延长的关系。
Br J Pharmacol. 2011 Sep;164(2):260-73. doi: 10.1111/j.1476-5381.2011.01415.x.
5
Cardiac function and antiepileptic drug treatment in the elderly: a comparison between lamotrigine and sustained-release carbamazepine.老年人的心脏功能与抗癫痫药物治疗：拉莫三嗪与缓释卡马西平的比较
Epilepsia. 2009 Aug;50(8):1841-9. doi: 10.1111/j.1528-1167.2009.02069.x. Epub 2009 Mar 23.
6
Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects.在一项针对健康受试者的全面QT/QTc研究中，拉莫三嗪不会延长QTc间期。
Br J Clin Pharmacol. 2008 Sep;66(3):396-404. doi: 10.1111/j.1365-2125.2008.03250.x. Epub 2008 Jul 23.

FDA safety warning on the cardiac effects of lamotrigine: An advisory from the Ad Hoc ILAE/AES Task Force.

作者信息

French Jacqueline A, Perucca Emilio, Sander Josemir W, Bergfeldt Lennart, Baulac Michel, Auerbach David S, Keezer Mark, Thijs Roland D, Devinsky Orrin, Vossler David G, Welty Timothy E

机构信息

Department of Neurology, New York University Grossman School of Medicine and NYU Langone Health, New York, NY, USA.

Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

出版信息

Epilepsia Open. 2021 Feb 25;6(1):45-48. doi: 10.1002/epi4.12475. eCollection 2021 Mar.

DOI:10.1002/epi4.12475
PMID:33681647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7918301/
Abstract
摘要