Fenton M A, Yang T J
Department of Pathobiology, University of Connecticut, Storrs.
Oncology. 1988;45(3):210-3. doi: 10.1159/000226564.
Canine transmissible venereal sarcoma (CTVS) is a contagious neoplasm which regresses spontaneously in adult dogs but metastasizes and kills puppies transplanted with the neoplasm at a very young age. Immunofluorescence studies showed that 30 +/- 14% of cells from steady-state and 22 +/- 7% of cells from regressing tumors had membrane-bound antibodies which could be eluted out with warm washes at 24 degrees C, whereas the cells from progressor tumors had very little such antibody (6 +/- 6%). Time-course kinetics of anti-CTVS antibodies in the serum of tumor-bearing dogs did not correlate well with tumor volume, however, the presence of such antibodies in adult dogs (47 +/- 13%) but absence (0%) in the puppies with tumor metastasis suggested the importance of antibodies in resistance to metastasis.
犬传染性性病肉瘤（CTVS）是一种传染性肿瘤，在成年犬中可自发消退，但在非常年幼时移植该肿瘤的幼犬会发生转移并死亡。免疫荧光研究表明，来自稳态肿瘤的细胞中有30±14%以及来自消退肿瘤的细胞中有22±7%具有膜结合抗体，这些抗体可在24℃下用温热冲洗液洗脱，而进展性肿瘤的细胞中此类抗体很少（6±6%）。荷瘤犬血清中抗CTVS抗体的时间进程动力学与肿瘤体积相关性不佳，然而，成年犬中存在此类抗体（47±13%），而发生肿瘤转移的幼犬中不存在此类抗体（0%），这表明抗体在抵抗转移方面具有重要作用。
