Lafuente-Ibáñez de Mendoza Irene, Aguirre-Urizar José Manuel, Villatoro-Ugalde Verónica, Magaña-Quiñones José-Julio, Lana-Ojeda Jessica, Mosqueda-Taylor Adalberto
Unit of Oral Pathology and Medicine, Department of Stomatology II, University of the Basque Country/ EHU, Leioa, Spain.
Faculty of Dentistry, Intercontinental University, Mexico City, Mexico.
Oral Dis. 2022 May;28(4):1198-1206. doi: 10.1111/odi.13834. Epub 2021 Mar 21.
The aim of this study is to present and discuss the salient clinicopathological features, differential diagnosis and epithelial immunohistochemical profile of three additional cases of peripheral odontogenic keratocyst (POKC) and to present a review of the literature. POKC is a locally aggressive odontogenic lesion. The peripheral variant of the odontogenic keratocyst is rare and more frequently located in anterior gingiva.
We present the clinicopathological features of 3 new cases of POKC (2 women and 1 man; age range: 14-74 years). Immunohistochemical study included CK7, CK14, CK19 and Ki-67, and a systematic review of the literature was performed in PubMed, Scopus and Web of Science databases.
All cases were located in the anterior gingiva (2 in maxilla and 1 mandible), and none corresponded to Gorlin-Goltz syndrome. High expression of CK14 was seen in all cases, with CK19 and CK7 been only focally positive. The expression of Ki-67 was located in the basal and parabasal cells in all cases.
POKC is a rare gingival lesion that seems to originate from remnants of dental lamina or from the basal cells of the gingival epithelium and present a similar histopathology as compared to intraosseous OKC.
本研究旨在呈现并讨论另外三例外周性牙源性角化囊肿（POKC）的显著临床病理特征、鉴别诊断及上皮免疫组化特征，并对文献进行综述。POKC是一种具有局部侵袭性的牙源性病变。牙源性角化囊肿的外周型罕见，且更常位于前牙龈。
我们呈现了3例POKC新病例的临床病理特征（2例女性和1例男性；年龄范围：14 - 74岁）。免疫组化研究包括CK7、CK14、CK19和Ki-67，并在PubMed、Scopus和Web of Science数据库中对文献进行了系统综述。
所有病例均位于前牙龈（上颌2例，下颌1例），且均与戈林 - 戈尔茨综合征无关。所有病例中均可见CK14高表达，CK19和CK7仅局灶阳性。所有病例中Ki-67的表达位于基底细胞和副基底细胞。
POKC是一种罕见的牙龈病变，似乎起源于牙板残余或牙龈上皮的基底细胞，与骨内型牙源性角化囊肿相比具有相似的组织病理学表现。
