Department of Rehabilitation Medicine, Kyungpook National University Hospital, Jung-gu, Daegu 41944, Korea.
Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Korea.
Technol Health Care. 2021;29(S1):35-48. doi: 10.3233/THC-218004.
Post-stroke depression (PSD) is a consequential neuropsychiatric sequela that occurs after stroke. However, the pathophysiology of PSD are not well understood yet.
To explore alterations in functional connectivity (FC) between anterior insula and fronto-cortical and other subcortical regions in the non-affected hemisphere in patients with PSD compared to without PSD and healthy control.
Resting-state FC was estimated between the anterior insula and cortical and subcortical brain regions in the non-affected hemisphere in 13 patients with PSD, 12 patients without PSD, and 13 healthy controls. The severity of depressive mood was measured by the Beck Depression Inventory (BDI)-II.
Patients with PSD showed significant differences in FC scores between the anterior insula and the superior frontal, middle frontal, and orbitofrontal gyrus in the non-affected hemisphere than healthy control or patients without PSD (P< 0.05). In post-hoc, patients with PSD showed higher FC scores between the anterior insula and the superior frontal region than patients without PSD (P< 0.05). Furthermore, alterations in FC of the superior frontal, middle frontal, and orbitofrontal gyrus were positively correlated with depression severity, as measured with the BDI-II (P< 0.001).
中风后出现的抑郁（PSD）是一种重要的神经精神后遗症。然而，PSD 的病理生理学尚未得到很好的理解。
与无 PSD 和健康对照组相比，探讨 PSD 患者未受影响半球的前岛叶与额皮质和其他皮质下区域之间的功能连接（FC）变化。
在 13 名 PSD 患者、12 名无 PSD 患者和 13 名健康对照者中，评估了前岛叶与未受影响半球的皮质和皮质下脑区之间的静息状态 FC。抑郁情绪的严重程度用贝克抑郁量表（BDI-II）进行测量。
与健康对照组或无 PSD 患者相比，PSD 患者未受影响半球的前岛叶与额上回、额中回和眶额回之间的 FC 评分存在显著差异（P<0.05）。在后测中，PSD 患者前岛叶与额上回之间的 FC 评分高于无 PSD 患者（P<0.05）。此外，额上回、额中回和眶额回的 FC 改变与 BDI-II 评估的抑郁严重程度呈正相关（P<0.001）。
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