Department of Neuroscience, Carleton University Ottawa, ON, Canada.
Front Hum Neurosci. 2012 Dec 3;6:323. doi: 10.3389/fnhum.2012.00323. eCollection 2012.
Major depressive disorder (MDD) is characterized by a dysregulated fronto-limbic network. The hyperactivation of limbic regions leads to increased attention and processing of emotional information, with a bias toward negative stimuli. Pathological ruminative behavior is a common symptom of depressive disorder whereby the individual is unable to disengage from internal mental processing of emotionally salient events. In fact, lower deactivations of the neural baseline resting state may account for the increased internal self-focus. The insular cortex, with its extensive connections to fronto-limbic and association areas has recently also been implicated to be a part of this network. Given its wide-reaching connectivity, it has been putatively implicated as an integration center of autonomic, visceromotor, emotional, and interoceptive information. The following paper will review recent imaging findings of altered insular function and connectivity in depressive pathology.
重度抑郁症（MDD）的特征是额 - 边缘网络失调。边缘区域的过度激活导致对情绪信息的注意力和处理增加，对负面刺激存在偏向。病理性反刍行为是抑郁症的常见症状，个体无法从对情绪相关事件的内部心理加工中解脱出来。事实上，神经基线静息状态的去激活减少可能是导致内部自我关注增加的原因。岛叶皮层与额 - 边缘和联合区域广泛连接，最近也被认为是该网络的一部分。鉴于其广泛的连通性，它被推测为自主神经、内脏运动、情绪和内脏感觉信息的整合中心。以下论文将回顾抑郁病理中岛叶功能和连通性改变的最新影像学发现。
