囊性纤维化肺部病变的定量分析——数字胸部断层合成与计算机断层扫描的比较。
QUANTIFICATION OF PULMONARY PATHOLOGY IN CYSTIC FIBROSIS-COMPARISON BETWEEN DIGITAL CHEST TOMOSYNTHESIS AND COMPUTED TOMOGRAPHY.
机构信息
Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Bruna stråket 11b V 2 SU/Sahlgrenska, 413 45 Gothenburg, Sweden.
Department of Radiology and Nuclear Medicine, Oslo University Hospital, Nydalen 0424 Oslo, Norway.
出版信息
Radiat Prot Dosimetry. 2021 Oct 12;195(3-4):434-442. doi: 10.1093/rpd/ncab017.
PURPOSE
Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF).
METHODS
DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α).
MAJOR FINDINGS
The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS.
CONCLUSION
Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.
目的
数字断层合成术（DTS）目前正在验证其在临床应用方面的潜力。本研究旨在探讨 DTS 作为一种低剂量替代 CT 成像技术，用于囊性纤维化（CF）患者肺部病变成像的可能性。
方法
DTS 和 CT 作为 CF 患者三年一次的常规随访的一部分进行。根据特定于模态的评分系统对疾病程度进行量化。统计分析包括 Spearman 秩相关系数（r）和 Krippendorff 的α（α）。
主要发现
DTS 的平均有效剂量为 0.14，CT 为 2.68。总评分以及支气管扩张和支气管壁增厚的亚评分的两种模式之间的相关性非常强（r=0.82-0.91，P<0.01）。DTS 中总评分、支气管扩张和黏液嵌塞的观察者间可靠性较高（α=0.83-0.93）。
结论
胸部断层合成术可能是 CF 患者定量评估结构性肺部疾病的 CT 低剂量替代方法。
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