Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Transplantation, The Second Affiliated Hospital of Southern University of Science and Technology and the Third People's Hospital of Shenzhen, Shenzhen, China.
Pediatr Pulmonol. 2021 Jun;56(6):1455-1463. doi: 10.1002/ppul.25335. Epub 2021 Mar 8.
Strict countermeasures for coronavirus disease (COVID-19) were undertaken in China without knowing their influence on asthma.
To investigate the associations between the frequencies of asthma exacerbations and respiratory infections and air pollutants before and during the COVID-19 pandemic, which were direct consequences of countermeasures undertaken for the pandemic.
Asthma exacerbations and respiratory infections among hospitalized children in the permanent population of Guangzhou City, China, from February to June 2016-2019 (before the pandemic) to February to June 2020 (during the pandemic) were collected in this cross-sectional study in Guangzhou.
The number of asthma exacerbation cases per month documented in the Guangzhou Women and Children's Hospital before (median: 13.5; range: 0-48) and during (median: 20; range: 0-34) the mitigative response to the COVID-19 pandemic was similar. The frequency of severe asthma exacerbation cases per month decreased, whereas that of mild asthma exacerbation cases per year increased (p = .004). The number of patients hospitalized with infectious respiratory diseases decreased from 146 (range: 90-172) per month before the pandemic to 42 (range: 33-57) per month during the pandemic (p = .004). Most pathogens and air pollutants decreased during the COVID-19 pandemic. The frequency of severe asthma exacerbations positively correlated to that of respiratory infections in children, but did not correlate to air pollutants.
Strict countermeasures undertaken for the pandemic were associated with a decreased the frequency of infectious respiratory diseases and severe asthma exacerbations among urban children.
中国在未知其对哮喘影响的情况下采取了严格的新冠疫情防控措施。
调查新冠疫情期间采取的疫情防控措施导致的哮喘恶化和呼吸道感染及空气污染频率变化与哮喘之间的关联。
本横断面研究在广州市收集了 2016 年 2 月至 2019 年 2 月（疫情前）和 2020 年 2 月至 6 月（疫情期间）期间常住儿童在广州市妇女儿童医疗中心因哮喘住院的哮喘恶化和呼吸道感染情况。
在广州妇女儿童医疗中心，疫情防控措施缓解期（中位数：20；范围：0-34）与疫情前（中位数：13.5；范围：0-48）相比，每月记录的哮喘恶化病例数相似。每月严重哮喘恶化病例数减少，而每年轻度哮喘恶化病例数增加（p = .004）。因传染性呼吸道疾病住院的患者人数从疫情前每月 146 例（范围：90-172）降至疫情期间每月 42 例（范围：33-57）（p = .004）。大多数病原体和空气污染物在新冠疫情期间减少。儿童严重哮喘恶化频率与呼吸道感染频率呈正相关，但与空气污染物无关。
针对新冠疫情采取的严格防控措施与城市儿童传染性呼吸道疾病和严重哮喘恶化频率降低有关。
