G.A Ushakova Department of Obstetrics and Gynecology, the State Medical University, Kemerovo, Russia.
Department of Gynecology, L. A. Reshetova Regional Perinatal Centre, Kemerovo, Russia.
Horm Mol Biol Clin Investig. 2021 Mar 9;42(3):285-289. doi: 10.1515/hmbci-2020-0056.
The objective of the study was to determine the level of antibodies (AB) of Ig classes A and G to estradiol (E2), progesterone (P) and benzo [a] pyrene (Bp) in patients with endometriosis of various severity and estimate their threshold values as a risk factor for the development of endometriosis.
A retrospective case-control study was performed. The study involved 200 women. Group I: women with endometriosis (n=100), Group II: patients with tubal-peritoneal infertility (n=100). All patients underwent immunological studies of blood serum; and the levels of steroid hormones (P, E2), antibodies to them and Bp were determined. A ROC analysis was carried out to identify threshold values of antibodies levels.
Women with endometriosis were found to have statistically significantly higher levels of antibodies IgA and IgG to E2, P and benzo [a] pyrene compared to women of Group II. The threshold levels of IgA-Bp, IgA-E2 and IgA-P are >5 CU (conventional unit), IgG-Bp, IgG-E2>9 CU and IgG-P>8 CU. The level of IgG-P in patients with severe forms of endometriosis is statistically significantly higher than in minor forms of the disease. In case of severe forms, there is a tendency to increasing other classes of antibodies.
Patients with endometriosis usually have a higher level of IgA and IgG to Bp, E2, P. Their threshold values, which are risk factors for the development of the disease, are estimated.
本研究旨在确定不同严重程度子宫内膜异位症患者的 IgA 和 IgG 类抗体（AB）对雌二醇（E2）、孕酮（P）和苯并[a]芘（Bp）的水平，并评估其作为子宫内膜异位症发病风险因素的阈值。
本研究采用回顾性病例对照研究。研究共纳入 200 名女性。I 组：子宫内膜异位症患者（n=100）；II 组：输卵管-腹膜不孕患者（n=100）。所有患者均接受血清免疫学研究，检测甾体激素（P、E2）、针对它们的抗体和 Bp 的水平。进行 ROC 分析以确定抗体水平的阈值。
与 II 组女性相比，子宫内膜异位症患者的 E2、P 和 Bp 的 IgA 和 IgG 抗体水平均显著升高。IgA-Bp、IgA-E2 和 IgA-P 的阈值水平>5 CU（常规单位），IgG-Bp、IgG-E2>9 CU，IgG-P>8 CU。严重形式子宫内膜异位症患者的 IgG-P 水平明显高于轻度形式。在严重形式的情况下，其他类别的抗体水平呈上升趋势。
子宫内膜异位症患者通常具有更高水平的 Bp、E2、P 的 IgA 和 IgG。评估了它们的阈值，这些阈值是疾病发展的风险因素。
