摩洛哥哺乳期母亲母乳中的铅浓度及其暴露的相关因素：CONTAMILK 研究。
Lead concentrations in breast milk of Moroccan nursing mothers and associated factors of exposure: CONTAMILK STUDY.
机构信息
Unit of training and research in Nutrition and Food Science. Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco; Laboratory of analytical chemistry and food science, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
University Mohammed V, Rabat, Morocco.
出版信息
Environ Toxicol Pharmacol. 2021 Jul;85:103629. doi: 10.1016/j.etap.2021.103629. Epub 2021 Mar 5.
The aim of CONTAMILK study was to estimate levels of contamination of breast milk (BM) of Moroccan nursing mothers by some xenobiotics including, lead (Pb), to identify associated factors of exposure and to determine the daily intake of newborns. Lead concentrations were determined in 70 samples of colostrum by ICPMS and a structured questionnaire was filled during milk collection to report participants' data. The median lead concentration was 908 μg/L (range 1.38-515,39 μg/L) and in 79 % of samples, levels were higher than the normal range reported by the World Health Organization (WHO) in BM (2-5 μg/L). Indeed, preterm delivery, frequency of use of cosmetic powders and lipsticks were significantly associated with the level of lead in BM. The estimated daily intake was greater than the tolerable daily intake (TDI) of the European food safety authority (0.5 μg/kg/day) for 39 babies and 6 babies according to the WHO (3.6 μg/kg/day).
CONTAMILK 研究旨在评估摩洛哥哺乳期母亲母乳（BM）中某些外源性化学物质（包括铅（Pb））的污染水平，确定其暴露的相关因素，并确定新生儿的日摄入量。通过电感耦合等离子体质谱法（ICPMS）测定了 70 份初乳样本中的铅浓度，并在采集母乳期间填写了一份结构化问卷，以报告参与者的数据。铅浓度的中位数为 908μg/L（范围为 1.38-515.39μg/L），79%的样本中，其水平高于世界卫生组织（WHO）在 BM（2-5μg/L）中报告的正常值。事实上，早产、使用化妆品粉和口红的频率与 BM 中的铅水平显著相关。根据欧洲食品安全局（EFSA）的可耐受日摄入量（TDI）（0.5μg/kg/天），39 名婴儿和 6 名婴儿的估计日摄入量超过了该值，而根据世卫组织（3.6μg/kg/天）的标准，6 名婴儿的摄入量超过了该值。
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