Hamlin M N, Webb R C, Ling W D, Bohr D F
Department of Physiology, University of Michigan, Ann Arbor 48109.
Proc Soc Exp Biol Med. 1988 May;188(1):46-51. doi: 10.3181/00379727-188-42705.
Salt appetite was quantified in sheep by measuring the relative amounts of high-salt (266 meq/kg) and low-salt (6 meq/kg) pelleted alfalfa that they ate. Given a choice of these two foods, normal sheep ate twice as much low-salt as high-salt pellets. Following DOCA administration the sheep rapidly developed an increased salt appetite, and after 10 days they ate approximately three times as much high-salt as low-salt pellets. Their choice rapidly reverted to control values after the end of the DOCA treatment. The changes in salt appetite were accompanied by changes in thirst and mean arterial pressure. We hypothesize that these effects of DOCA reflect changes that parallel those this mineralocorticoid causes in the hypothalamic regulatory centers for salt appetite, thirst, and blood pressure.
通过测量绵羊食用的高盐（266 毫当量/千克）和低盐（6 毫当量/千克）苜蓿颗粒的相对量来量化其盐食欲。在这两种食物可供选择时，正常绵羊食用的低盐颗粒量是高盐颗粒量的两倍。给予 DOCA 后，绵羊的盐食欲迅速增加，10 天后它们食用的高盐颗粒量约为低盐颗粒量的三倍。DOCA 治疗结束后，它们的选择迅速恢复到对照值。盐食欲的变化伴随着口渴和平均动脉压的变化。我们推测，DOCA 的这些作用反映了与这种盐皮质激素在下丘脑盐食欲、口渴和血压调节中心所引起的变化相似的变化。
