哺乳动物前肢进化发育中的非模式系统。
Non-model systems in mammalian forelimb evo-devo.
机构信息
Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA, 90095, United States.
Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA, 90095, United States; Centre for Craniofacial and Regenerative Biology, King's CollegeLondon, 27th Floor Guy's Tower, London, SE1 9RT, UK.
出版信息
Curr Opin Genet Dev. 2021 Aug;69:65-71. doi: 10.1016/j.gde.2021.01.012. Epub 2021 Mar 6.
Mammal forelimbs are highly diverse, ranging from the elongated wing of a bat to the stout limb of the mole. The mammal forelimb has been a long-standing system for the study of early developmental patterning, proportional variation, shape change, and the reduction of elements. However, most of this work has been performed in mice, which neglects the wide variation present across mammal forelimbs. This review emphasizes the critical role of non-model systems in limb evo-devo and highlights new emerging models and their potential. We discuss the role of gene networks in limb evolution, and touch on functional analyses that lay the groundwork for further developmental studies. Mammal limb evo-devo is a rich field, and here we aim to synthesize the findings of key recent works and the questions to which they lead.
哺乳动物的前肢高度多样化，从蝙蝠的长翅膀到鼹鼠的粗壮肢。哺乳动物的前肢一直是研究早期发育模式、比例变化、形状变化和元素减少的长期系统。然而，这项工作大多是在老鼠身上进行的，这忽视了哺乳动物前肢的广泛变化。本综述强调了非模型系统在肢体进化发育中的关键作用，并突出了新出现的模型及其潜力。我们讨论了基因网络在肢体进化中的作用，并涉及为进一步发育研究奠定基础的功能分析。哺乳动物肢体进化发育是一个丰富的领域，在这里，我们旨在综合关键的最新研究成果及其所带来的问题。
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